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1,N6-etheno-2-azaadenosine-2',3'-cyclic monophosphate + H2O
etheno-2-azaadenosine-2'-monophosphate
-
-
-
?
1,N6-ethenoadenosine-2',3'-cyclic monophosphate + H2O
ethenoadenosine-2'-monophosphate
-
-
-
?
2', 3'-cyclic ribonucleotide
ribonucleoside 2'-phosphate
-
-
-
?
2',3'-cAMP + H2O
2'-AMP + 3'-AMP
-
-
?
2',3'-cAMP + H2O
3'-AMP + ?
-
the exclusive formation of 3'-AMP is due to the P-O2' bond having lower activation energy and is not the result of steric exclusion at enzyme active site, kinetic evidence that hydrolysis of 2',3'-cAMP into 3'-AMP is nonspecific. Modeling of 2',3'-cyclic nucleotide into the active site of a EAL domain PDE, overview
-
?
2',3'-cGMP + H2O
2'-GMP + 3'-GMP
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
2',3'-cNADP+ + H2O
?
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
2',3'-cyclic NADP+ + H2O
NADP+
2',3'-cyclic-2-aza-e-AMP + H2O
2'-2-aza-e-AMP
-
-
-
?
2',3'-cyclic-e-AMP + H2O
2'-e-AMP
-
-
-
?
2'-AMP + H2O
adenosine + phosphate
-
-
?
adenosine 2,3-cyclic phosphorothioate + H2O
?
the Sp epimer of 2',3'-cAMPS is a functional substrate for the enzyme, while the Rp epimer is not
-
?
ADP + H2O
AMP + phosphate
-
-
?
ATP + H2O
ADP + phosphate
-
-
?
bis(p-nitrophenyl)phosphate + H2O
?
-
non-specific substrate
-
?
bis-p nitrophenyl phosphate + H2O
?
-
-
-
?
bis-p-nitrophenyl phosphate + H2O
?
-
-
?
CDP + H2O
CMP + phosphate
-
-
?
CTP + H2O
CDP + phosphate
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
cyclic 2',3'-CMP + H2O
2'-CMP
low activity
-
?
cyclic 2',3'-GMP + H2O
2'-GMP
high activity
-
?
diphosphate + H2O
2 phosphate
-
-
?
NADP+ + H2O
NAD+ + phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
nucleoside 2',3'-cyclic phosphates + H2O
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
?
additional information
?
-
2',3'-cAMP + H2O

2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
the protein consists of two domains: an uncharacterized N-terminal domain with little homology to other proteins, and a C-terminal phosphodiesterase domain. C-terminal tail (22 residues) has no significant effect on the catalytic activity, neither do the first 24 N-terminal residues of the full-length protein. Both the N- and C-terminal domain of recombinant CNPase are folded entities: N-terminal domain has more beta-sheet structure and less alpha-helices than the C-terminal domain
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cCMP + H2O

2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cGMP + H2O

2'-GMP
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
?
2',3'-cNADP+ + H2O

2'-NADP+
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
?
2',3'-cNADP+ + H2O

NADP+
-
-
?
2',3'-cNADP+ + H2O
NADP+
-
-
-
?
2',3'-cNADP+ + H2O
NADP+
-
-
-
?
2',3'-cUMP + H2O

2'-UMP
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
?
2',3'-cyclic AMP + H2O

2'-AMP
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
product binding structure, overview
-
?
2',3'-cyclic AMP + H2O
2'-AMP
substrate and product enzyme binding structures, overview
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
?
2',3'-cyclic NADP+ + H2O

NADP+
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
?
cyclic 2',3'-AMP + H2O

2'-AMP
best substrate
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
natural substrate, the 2',3'-cyclic phosphodiesterase activity of the C-terminal HD domain of tRNA nucleotidyltransferase, EC 2.7.7.25, is involved in the repair of the 3ā-CCA end of tRNA
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O

nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
dinucleotide binding mode, overview
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
activity resides in the C-terminus
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
His-230 and His-309 of CNP1 play critical roles in enzyme catalysis, no essential role of cysteines, the catalytic domain forms a compact globular structure
-
ir
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
plays a role in cytoskeletal rearrangement, cell morphology and cell process outgrowth, increased expression of CNP is a marker for oligodendrocyte development
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O

?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
?
additional information

?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
not: nucleoside 3',5'-cyclic phosphate
-
?
additional information
?
-
not: nucleoside 3',5'-cyclic phosphate
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
endogenous Nogo-A interacts with the endogenous CNP in vitro and in vivo
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
early stages of myelin formation
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4 and nuclear factor-1 in the regulation of CNP1 expression
-
?
additional information
?
-
-
enzyme is involved in mediating process formation in oligodendrocytes
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
three enzyme forms
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
CNP acts as microtubule-associated protein in promoting microtubule assembly at low mole ratios, links tubulin to membranes and may regulate cytoplasmic microtubule distribution, membrane anchor for tubulin
-
?
additional information
?
-
-
CNP is one of the earliest myelin-related proteins to be expressed in differentiated oligodendrocytes and Schwann cells, role in migration and/or expansion of membranes during myelination
-
?
additional information
?
-
-
CNP performs an integral role in myelinogenesis, both isoforms likely play complementary roles in the onset of process outgrowth and ultimately myelination of axons
-
?
additional information
?
-
-
early oligodendroglial marker, CNPase links myelin related proteins to the cytoskeleton also interacting with membrane lipids during extension and wrapping of the oligodendroglial process around the axon, in mature myelinated fiber the CNPase is absent from compact myelin sheath, being located only in the inner and outer loops and in paranodal loops
-
?
additional information
?
-
-
myelin-specific protein, synthesized by oligodendrocytes, more abundant in the myelin of the CNS than in that of the peripheral nervous system, CNP is regulated by several protein kinases and may have a role in morphological changes of the cells by modulating the cytoskeleton
-
?
additional information
?
-
-
non-compact myelin protein, may have a unique role in signaling pathways mediated by lipid-protein domains
-
?
additional information
?
-
-
related to axonal ensheathment by myelinating cells
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4, nuclear factor-1 and protein kinase A in the regulation of CNP1 expression
-
?
additional information
?
-
-
endogenous enzyme expression is augmented by juxtanodin transfection, an oligodendroglial protein that promotes cellular arborization. Juxtanodin also augments transport of enzyme to the process arbors of cultured primary oligodendrocyte precursors
-
?
additional information
?
-
-
enzyme can perform the essential 3'-end-healing steps of tRNA splicing in yeast and complement growth of strains bearing lethal or temperature-sensitive mutations in the tRNA ligase 3'-end-healing domain
-
?
additional information
?
-
-
enzyme binds purine nucleotide triphosphates with an affinity higher than that displayed for diphosphates, while the affinity for both purine monophosphates and pyrimidine nucleotides is negligible. Analysis of binding constants for GTP, GDP, GMP, ATP, ADP, CTP, CDP, UTP, UDP
-
?
additional information
?
-
-
CNP is an RNA-binding protein, CNP associates with poly(A)+ mRNAs in vivo and suppresses translation in vitro in a dose-dependent manner, isoform CNP1 may regulate expression of mRNAs in oligodendrocytes of the central nervous system
-
?
additional information
?
-
-
substrate specificities and activities of RocR, DGC2, YybT, YtqI, 3DMA, and PaAcpH with 2',3'-cAMP, overview
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
additional information
?
-
-
not: 2',3'-cyclic esters in cyclic phosphate-terminated oligoribonucleotides or in nucleoside 5'-phosphate, 2',3'-cyclic phosphate
-
?
additional information
?
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
cyclic 2',3'-AMP + H2O
2'-AMP
natural substrate, the 2',3'-cyclic phosphodiesterase activity of the C-terminal HD domain of tRNA nucleotidyltransferase, EC 2.7.7.25, is involved in the repair of the 3ā-CCA end of tRNA
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
nucleoside 2',3'-cyclic phosphates + H2O
?
additional information
?
-
2',3'-cAMP + H2O

2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O

2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O

nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
plays a role in cytoskeletal rearrangement, cell morphology and cell process outgrowth, increased expression of CNP is a marker for oligodendrocyte development
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O

?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
additional information

?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
early stages of myelin formation
-
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4 and nuclear factor-1 in the regulation of CNP1 expression
-
?
additional information
?
-
-
enzyme is involved in mediating process formation in oligodendrocytes
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
CNP acts as microtubule-associated protein in promoting microtubule assembly at low mole ratios, links tubulin to membranes and may regulate cytoplasmic microtubule distribution, membrane anchor for tubulin
-
?
additional information
?
-
-
CNP is one of the earliest myelin-related proteins to be expressed in differentiated oligodendrocytes and Schwann cells, role in migration and/or expansion of membranes during myelination
-
?
additional information
?
-
-
CNP performs an integral role in myelinogenesis, both isoforms likely play complementary roles in the onset of process outgrowth and ultimately myelination of axons
-
?
additional information
?
-
-
early oligodendroglial marker, CNPase links myelin related proteins to the cytoskeleton also interacting with membrane lipids during extension and wrapping of the oligodendroglial process around the axon, in mature myelinated fiber the CNPase is absent from compact myelin sheath, being located only in the inner and outer loops and in paranodal loops
-
?
additional information
?
-
-
myelin-specific protein, synthesized by oligodendrocytes, more abundant in the myelin of the CNS than in that of the peripheral nervous system, CNP is regulated by several protein kinases and may have a role in morphological changes of the cells by modulating the cytoskeleton
-
?
additional information
?
-
-
non-compact myelin protein, may have a unique role in signaling pathways mediated by lipid-protein domains
-
?
additional information
?
-
-
related to axonal ensheathment by myelinating cells
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4, nuclear factor-1 and protein kinase A in the regulation of CNP1 expression
-
?
additional information
?
-
-
endogenous enzyme expression is augmented by juxtanodin transfection, an oligodendroglial protein that promotes cellular arborization. Juxtanodin also augments transport of enzyme to the process arbors of cultured primary oligodendrocyte precursors
-
-
?
additional information
?
-
-
enzyme can perform the essential 3'-end-healing steps of tRNA splicing in yeast and complement growth of strains bearing lethal or temperature-sensitive mutations in the tRNA ligase 3'-end-healing domain
-
-
?
additional information
?
-
-
CNP is an RNA-binding protein, CNP associates with poly(A)+ mRNAs in vivo and suppresses translation in vitro in a dose-dependent manner, isoform CNP1 may regulate expression of mRNAs in oligodendrocytes of the central nervous system
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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10
1,N6-Etheno-2-azaadenosine-2',3'-cyclic monophosphate
-
-
8.3
1,N6-Ethenoadenosine-2',3'-cyclic monophosphate
-
rat brain
0.483 - 39.648
2',3'-cNADP+
0.553 - 1.305
2',3'-Cyclic AMP
0.16
bis-p-nitrophenyl phosphate
-
-
0.49 - 100
cyclic 2',3'-AMP
1.6
cyclic 2',3'-GMP
pH 7, 37°C
0.1
diphosphate
+/- 0.004
6.2
p-nitrophenyl phosphate
+/- 0.46
additional information
additional information
-
0.25
2',3'-cAMP

-
-
0.32
2',3'-cAMP
-
H7-zRICH-WT mutant
0.38
2',3'-cAMP
-
pig cerebral white matter
0.39
2',3'-cAMP
-
H7-zRICH-C339A mutant
0.537
2',3'-cAMP
-
full-length protein
1.64
2',3'-cAMP
-
pH 6.2, 37°C
1.9
2',3'-cAMP
-
bovine brain
2.15
2',3'-cAMP
-
pH 6.2, 37°, treatment with lead
2.5
2',3'-cAMP
-
H7-zRICH-R332A mutant
0.8
2',3'-cCMP

-
bovine brain
5.6
2',3'-cCMP
-
bovine brain, elastase fragment
0.57
2',3'-cGMP

-
bovine brain
0.098
2',3'-cNADP

-
pH 6, 25°C, H309L mutant CNP1
0.1
2',3'-cNADP
-
pH 6, 25°C, H309F mutant CNP1
0.104
2',3'-cNADP
-
pH 6, 25°C, H230L mutant CNP1
0.119
2',3'-cNADP
-
pH 6, 25°C, H230F mutant CNP1
0.23
2',3'-cNADP
-
bovine spinal cord
0.231
2',3'-cNADP
-
pH 6, 25°C, C231A mutant CNP1
0.237
2',3'-cNADP
-
pH 6, 25°C, recombinant full-length CNP1
0.241
2',3'-cNADP
-
pH 6, 25°C, C314S mutant CNP1
0.295
2',3'-cNADP
-
pH 6, 25°C, catalytic fragment of CNP1 corresponding to the C-terminal 250 amino acids
0.333
2',3'-cNADP
-
pH 6, 25°C, C314A mutant CNP1
0.354
2',3'-cNADP
-
pH 6, 25°C, C236A mutant CNP1
0.379
2',3'-cNADP
-
pH 6, 25°C, C236S mutant CNP1
0.47
2',3'-cNADP
-
rat brain
0.473
2',3'-cNADP
-
pH 6, 25°C, C231S mutant CNP1
0.51
2',3'-cNADP
-
rat liver
0.483
2',3'-cNADP+

mutant enzyme P225G, pH and temperature not specified in the publication
0.553
2',3'-cNADP+
wild type enzyme, pH and temperature not specified in the publication
0.722
2',3'-cNADP+
mutant enzyme P296G, pH and temperature not specified in the publication
1.045
2',3'-cNADP+
mutant enzyme V321A, pH and temperature not specified in the publication
1.055
2',3'-cNADP+
mutant enzyme H230Q, pH and temperature not specified in the publication
1.192
2',3'-cNADP+
mutant enzyme H309S, pH and temperature not specified in the publication
1.305
2',3'-cNADP+
mutant enzyme H230S, pH and temperature not specified in the publication
1.385
2',3'-cNADP+
mutant enzyme Y168S, pH and temperature not specified in the publication
1.879
2',3'-cNADP+
mutant enzyme Y168A, pH and temperature not specified in the publication
2.192
2',3'-cNADP+
mutant enzyme R307Q, pH and temperature not specified in the publication
3.788
2',3'-cNADP+
mutant enzyme F235L, pH and temperature not specified in the publication
6.253
2',3'-cNADP+
mutant enzyme F235A, pH and temperature not specified in the publication
39.648
2',3'-cNADP+
mutant enzyme T232A, pH and temperature not specified in the publication
8.3
2',3'-cUMP

-
bovine brain
0.553
2',3'-Cyclic AMP

wild-type enzyme, pH and temperature not specified in the publication
1.045
2',3'-Cyclic AMP
mutant V321A, pH and temperature not specified in the publication
1.055
2',3'-Cyclic AMP
mutant H230Q, pH and temperature not specified in the publication
1.192
2',3'-Cyclic AMP
mutant H309S, pH and temperature not specified in the publication
1.305
2',3'-Cyclic AMP
mutant H230S, pH and temperature not specified in the publication
0.49
cyclic 2',3'-AMP

pH 7, 37°C
3.9
cyclic 2',3'-AMP
-
mutant H376D, pH 7.5, 45°C
4.7
cyclic 2',3'-AMP
-
mutant H376N, pH 7.5, 45°C
6.6
cyclic 2',3'-AMP
-
mutant D236N, pH 7.5, 45°C
7.8
cyclic 2',3'-AMP
-
mutant D236A, pH 7.5, 45°C
18
cyclic 2',3'-AMP
-
mutant D236E, pH 7.5, 45°C
18
cyclic 2',3'-AMP
-
mutant D392E, pH 7.5, 45°C
18
cyclic 2',3'-AMP
-
wild-type, pH 7.5, 45°C
20
cyclic 2',3'-AMP
-
mutant H189D, pH 7.5, 45°C
24
cyclic 2',3'-AMP
-
mutant H323Q, pH 7.5, 45°C
28
cyclic 2',3'-AMP
-
mutant H189E, pH 7.5, 45°C
29
cyclic 2',3'-AMP
-
mutant H189A, pH 7.5, 45°C
31
cyclic 2',3'-AMP
-
mutant D392N, pH 7.5, 45°C
32
cyclic 2',3'-AMP
-
mutant H323A, pH 7.5, 45°C
60
cyclic 2',3'-AMP
-
mutant R237Q, pH 7.5, 45°C
62
cyclic 2',3'-AMP
-
mutant D233E, pH 7.5, 45°C
77
cyclic 2',3'-AMP
-
mutant R237A, pH 7.5, 45°C
100
cyclic 2',3'-AMP
-
mutant D392A, pH 7.5, 45°C
100
cyclic 2',3'-AMP
-
mutant R237K, pH 7.5, 45°C
additional information
additional information

-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
three enzyme forms
-
additional information
additional information
-
in the prescence of serum albumin or hexadecyltrimethylammonium bromide
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
14 - 940
2',3'-Cyclic AMP
0.031 - 34.3
cyclic 2',3'-AMP
1.97 - 2.94
cyclic 2',3'-GMP
2.51
diphosphate
+/- 0.05
10.3
p-nitrophenyl phosphate
+/- 0.28
additional information
additional information
-
-
-
7.63
2',3'-cAMP

+/- 0.48
118
2',3'-cAMP
-
full-length protein
1.15
2',3'-cNADP

-
pH 6, 25°C, H230F mutant CNP1
1.16
2',3'-cNADP
-
pH 6, 25°C, H230L mutant CNP1
1.27
2',3'-cNADP
-
pH 6, 25°C, H309L mutant CNP1
1.35
2',3'-cNADP
-
pH 6, 25°C, H309F mutant CNP1
6.08
2',3'-cNADP
-
pH 6, 25°C, H230L mutant CNP1
6.08
2',3'-cNADP
-
pH 6, 25°C, H309L mutant CNP1
594
2',3'-cNADP
-
pH 6, 25°C, C314S mutant CNP1
825
2',3'-cNADP
-
pH 6, 25°C, C231S mutant CNP1
968
2',3'-cNADP
-
pH 6, 25°C, C231A mutant CNP1
1107
2',3'-cNADP
-
pH 6, 25°C, C236S mutant CNP1
1110
2',3'-cNADP
-
pH 6, 25°C, C236S mutant CNP1
1116
2',3'-cNADP
-
pH 6, 25°C, C314A mutant CNP1
1120
2',3'-cNADP
-
pH 6, 25°C, C314A mutant CNP1
1130
2',3'-cNADP
-
pH 6, 25°C, C397S mutant CNP1
1132
2',3'-cNADP
-
pH 6, 25°C, C397S mutant CNP1
1195
2',3'-cNADP
-
pH 6, 25°C, recombinant full-length wild-type CNP1
1200
2',3'-cNADP
-
pH 6, 25°C, recombinant full-length wild-type CNP1
1476
2',3'-cNADP
-
pH 6, 25°C, C236A mutant CNP1
1480
2',3'-cNADP
-
pH 6, 25°C, C236A mutant CNP1
1690
2',3'-cNADP
-
pH 6, 25°C, catalytic fragment of CNP1 corresponding to the C-terminal 250 amino acids
14
2',3'-cNADP+

mutant enzyme H230S, pH and temperature not specified in the publication
21
2',3'-cNADP+
mutant enzyme H309S, pH and temperature not specified in the publication
24
2',3'-cNADP+
mutant enzyme H230Q, pH and temperature not specified in the publication
183
2',3'-cNADP+
mutant enzyme F235A, pH and temperature not specified in the publication
221
2',3'-cNADP+
mutant enzyme F235L, pH and temperature not specified in the publication
231
2',3'-cNADP+
mutant enzyme T232A, pH and temperature not specified in the publication
237
2',3'-cNADP+
mutant enzyme Y168A, pH and temperature not specified in the publication
732
2',3'-cNADP+
mutant enzyme V321A, pH and temperature not specified in the publication
887
2',3'-cNADP+
mutant enzyme Y168S, pH and temperature not specified in the publication
940
2',3'-cNADP+
wild type enzyme, pH and temperature not specified in the publication
1182
2',3'-cNADP+
mutant enzyme R307Q, pH and temperature not specified in the publication
1332
2',3'-cNADP+
mutant enzyme P296G, pH and temperature not specified in the publication
1420
2',3'-cNADP+
mutant enzyme P225G, pH and temperature not specified in the publication
14
2',3'-Cyclic AMP

mutant H230S, pH and temperature not specified in the publication
21
2',3'-Cyclic AMP
mutant H309S, pH and temperature not specified in the publication
24
2',3'-Cyclic AMP
mutant H230Q, pH and temperature not specified in the publication
732
2',3'-Cyclic AMP
mutant V321A, pH and temperature not specified in the publication
940
2',3'-Cyclic AMP
wild-type enzyme, pH and temperature not specified in the publication
0.031 - 0.51
cyclic 2',3'-AMP

pH 7, 37°C
1.45
cyclic 2',3'-AMP
-
mutant H189A, pH 7.5, 45°C
1.8
cyclic 2',3'-AMP
-
mutant D392A, pH 7.5, 45°C
3.2
cyclic 2',3'-AMP
-
mutant H376D, pH 7.5, 45°C
3.25
cyclic 2',3'-AMP
-
mutant D233E, pH 7.5, 45°C
4.5
cyclic 2',3'-AMP
-
mutant D236A, pH 7.5, 45°C
5.1
cyclic 2',3'-AMP
-
mutant H376N, pH 7.5, 45°C
5.8
cyclic 2',3'-AMP
-
mutant D236N, pH 7.5, 45°C
6
cyclic 2',3'-AMP
-
mutant D236E, pH 7.5, 45°C
6.5
cyclic 2',3'-AMP
-
mutant H323Q, pH 7.5, 45°C
7.63
cyclic 2',3'-AMP
pH 7, 37°C
8.6
cyclic 2',3'-AMP
-
mutant R237A, pH 7.5, 45°C
8.9
cyclic 2',3'-AMP
-
wild-type, pH 7.5, 45°C
9.1
cyclic 2',3'-AMP
-
mutant H323A, pH 7.5, 45°C
15.9
cyclic 2',3'-AMP
-
mutant D392E, pH 7.5, 45°C
17.2
cyclic 2',3'-AMP
-
mutant H189E, pH 7.5, 45°C
18.7
cyclic 2',3'-AMP
-
mutant D392N, pH 7.5, 45°C
20.2
cyclic 2',3'-AMP
-
mutant R237Q, pH 7.5, 45°C
26.2
cyclic 2',3'-AMP
-
mutant R237K, pH 7.5, 45°C
34.3
cyclic 2',3'-AMP
-
mutant H189D, pH 7.5, 45°C
1.97
cyclic 2',3'-GMP

pH 7, 37°C
2.94
cyclic 2',3'-GMP
pH 7, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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