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3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

This is an abbreviated version!
For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.37

Reaction

nucleoside 2',3'-cyclic phosphate
+
H2O
=
Nucleoside 2'-phosphate

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Inhibitors

Inhibitors on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-dipropyl-8-(4-sulfophenyl)xanthine
-
41% inhibition at 1 mM, 75% inhibition at 10 mM
2'-AMP
3',5'-cAMP
-
-
3'-AMP
-
-
5'-AMP
5'-ATP
-
-
5,5'-dithiobis-(2-nitrobenzoic acid)
-
97% inhibition of the catalytic fragment of CNP1 in a time- and dose-dependent manner, kinetics, fully reversed by excess dithiothreitol or 2-mercaptoethanol, inhibition is attributable to steric effects of modification of Cys-236 and Cys-314 by the inhibitor
adenosine
-
-
arsenate
-
-
arsenite
-
-
Atractyloside
-
noncompetitive
basic fibroblast growth factor
-
-
-
Ca2+
-
74% inhibition at 0.5 mM
Caffeine
diethylpyrocarbonate
-
pH 6.5, 22°C, time-dependent inhibition, kinetics, completely reversed by 0.5 M hydroxylamine
diisopropyl fluoroacetate
-
-
Elastase
-
little inactivation
-
Fe3+
-
66% inhibition at 0.5 mM
Guanidinium chloride
-
-
heparin
HgCl2
iodoacetamide
-
-
KCN
-
62% inhibition of the catalytic fragment of CNP1
lead
-
90 days exposure of young adult rats to lead in drinking water, decrease both in enzyme protein content and activity
methyl mercury
-
-
methyl methanethiosulfonate
-
42% inhibition of the catalytic fragment of CNP1
MnCl2
NaCH3COO
-
-
p-chloromercuribenzoate
-
98% inhibition at 0.2 mM
physostygmine
-
-
PO43-
Polynucleotides
sulfhydryl reagent
-
-
-
theophylline
thimerosal
tRNA
10 nM, strong competitive inhibition of 2',3'-cyclic phosphodiesterase activity, inhibition is abolished by addition of Mg2+, Mn2+ or Ca2+, but not of Ni2+
Trypsin
-
tubercidin
-
-
Zn(CH3COO)2
-
-
additional information
-