3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.37

3.1.4.37

myelin

oligodendrocyte

glial

mbp

matter

astrocyte

nerve

demyelination

cord

fibrillary

sclerosis

myelin-associated

sheath

proteolipid

cerebral

oligodendroglial

corpus

schwann

callosum

sulfatide

microglia

nestin

galactocerebroside

sciatic

3\'-cyclic

myelin-specific

myelin-related

hypomyelination

5'-nucleotidase

myelinogenesis

neurofilament

galactolipids

medicine

diagnostics

luxol

ensheathing

cuprizone

quaking

cerebroside

paranodal

jimpy

cuprizone-induced

shiverer

myelin-like

myelin-forming

oligodendrocyte-specific

analysis

oligodendrogenesis

Reaction

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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Results	in table
35	Activating Compound
1145	AA Sequence
7	Application
1	CAS Registry Number
27	Cloned(Commentary)
8	Crystallization (Commentary)
284	Disease/ Diagnostics
11	Expression
39	General Information
8	General Stability
117	Inhibitors
19	kcat/KM [mM/s]
6	Ki Value [mM]
112	KM Value [mM]
72	Localization
37	Metals/Ions
72	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
631	Organism
38	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
3	pI Value
14	Posttranslational Modification
73	Protein Variants
22	Purification (Commentary)
4	Reaction
2	Reaction Type
136	Reference
287	Source Tissue
58	Specific Activity [micromol/min/mg]
10	Storage Stability
268	Substrates and Products (Substrate)
49	Subunits
102	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
72	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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Ca2+

2 entries

Co2+

Bacillus subtilis

activation of activity against bis-p-nitrophenyl phosphate

Mg2+

Mn2+

Ni2+

sulfate

two sulfate molecules are located in the vicinity of the catalytic site, the active-site sulfate mimics the substrate phosphate group and interacts with all 4 conserved residues of the two HxTx motifs and the two central water molecules in the catalytic site through H-bonds, being also in contact with the backbone carbonyl of Pro320 and bulk solvent. The second sulfate stabilizes the long alpha6-beta5 loop

730687

additional information

20 entries