3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.37

3.1.4.37

myelin

oligodendrocyte

glial

mbp

matter

astrocyte

nerve

demyelination

cord

fibrillary

sclerosis

myelin-associated

sheath

proteolipid

cerebral

oligodendroglial

corpus

schwann

callosum

sulfatide

microglia

nestin

galactocerebroside

sciatic

3\'-cyclic

myelin-specific

myelin-related

hypomyelination

5'-nucleotidase

myelinogenesis

neurofilament

galactolipids

medicine

diagnostics

luxol

ensheathing

cuprizone

quaking

cerebroside

paranodal

jimpy

cuprizone-induced

shiverer

myelin-like

myelin-forming

oligodendrocyte-specific

analysis

oligodendrogenesis

Reaction

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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Results	in table
35	Activating Compound
1145	AA Sequence
7	Application
1	CAS Registry Number
27	Cloned(Commentary)
8	Crystallization (Commentary)
284	Disease/ Diagnostics
11	Expression
39	General Information
8	General Stability
117	Inhibitors
19	kcat/KM [mM/s]
6	Ki Value [mM]
112	KM Value [mM]
72	Localization
37	Metals/Ions
72	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
631	Organism
38	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
3	pI Value
14	Posttranslational Modification
73	Protein Variants
22	Purification (Commentary)
4	Reaction
2	Reaction Type
136	Reference
287	Source Tissue
58	Specific Activity [micromol/min/mg]
10	Storage Stability
268	Substrates and Products (Substrate)
49	Subunits
102	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
72	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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acylation

isoprenylation

lipoprotein

a 13 residue C-terminal fragment is responsible for enzyme membrane anchoring. Lipidation of the 13 residue fragment is essential for the peptide to be folded and correctly positioned on the membrane surface

678336

phosphoprotein

8 entries

proteolytic modification

Rattus norvegicus

enzyme contains a mitochondrial targeting signal at the N-terminus. Import to mitochondria leads to cleavage of signal sequence yielding a mature, truncated form of CNP2 similar in size as CNP1. Phosphorylation of the signal sequence by protein kinase C inhibits translocation to mitochondria.

670268

side-chain modification

2 entries