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3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

This is an abbreviated version!
For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.37

Reaction

nucleoside 2',3'-cyclic phosphate
+
H2O
=
Nucleoside 2'-phosphate

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Temperature Stability

Temperature Stability on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
80% loss of activity, and completely eliminated after 20 min, Co2+ protects against heat inactivation
40
-
50% loss of activity after 5 min
50
-
completely inactivated after 5 min
50 - 70
-
inactivation
55
-
no loss of activity after 10 min
58
melting temperature
60
-
85% loss of activity after 15 min
65
-
20% loss of activity after 10 min
65 - 75
-
increase in the melting temperature induced by both pH 5.5 and high salt concentration. At pH 5.5, without NaCl: ca. 68°C and with 500 mM NaCl: ca. 75°C. At pH 7.5 without NaCl and with 500 mM NaCl: ca. 70°C
80
-
82.2% loss of activity after 10 min