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Disease on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
2',3'-cyclic-nucleotide 3'-phosphodiesterase deficiency
Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination.
Discovery and Roles of 2',3'-cAMP in Biological Systems.
Acute Kidney Injury
Discovery and Roles of 2',3'-cAMP in Biological Systems.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Suppression of glial activation is involved in the protection of IL-10 on maternal E. coli induced neonatal white matter injury.
Adrenal Gland Neoplasms
Histologic and Immunohistochemical Classification of 41 Bovine Adrenal Gland Neoplasms.
Alzheimer Disease
2',3'-cyclic nucleotide-3'-phosphodiesterase activity as an index of myelin in the post-mortem brains of patients with Alzheimer's disease.
Abundant extracellular myelin in the meninges of patients with multiple sclerosis.
Decreased brain levels of 2',3'-cyclic nucleotide-3'-phosphodiesterase in Down syndrome and Alzheimer's disease.
Bell Palsy
Virus-associated demyelination in the pathogenesis of Bell's palsy.
Brain Diseases
Biochemical changes in Cuprizone-induced spongiform encephalopathy. I. Changes in the activities of 2',3'-cyclic nucleotide 3'-phosphohydrolase, oligodendroglial ceramide galactosyl transferase, and the hydrolysis of the alkenyl group of alkenyl, acyl-glycerophospholipids by plasmalogenase in different regions of the brain.
Brain Injuries
Discovery and Roles of 2',3'-cAMP in Biological Systems.
Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro.
Brain Injuries, Traumatic
The Brain In Vivo Expresses the 2',3'-cAMP-Adenosine Pathway.
The myelin membrane-associated enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase: on a highway to structure and function.
Brain Neoplasms
2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in human brain tumours.
S-100 protein and 2',3'-cyclic nucleotide 3'-phosphohydrolase in human brain tumors.
Cataract
2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway.
Demyelinating Diseases
2',3'-Cyclic nucleotide 3'-phosphodiesterase activity in the cerebrospinal fluid of patients with demyelinating diseases.
2',3'-cyclic nucleotide 3'-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases.
2',3'-cyclic nucleotide 3'-phosphohydrolase activity in rat visual pathways with experimental allergic encephalomyelitis.
A functional role for EGFR signaling in myelination and remyelination.
A single intracerebral microinjection of platelet-derived growth factor (PDGF) accelerates the rate of remyelination in vivo.
Activity of 2',3'-cyclic-nucleotide 3'-phosphodiesterase in cerebrospinal fluid of patients with demyelinating disorders.
Administration of vitamin D3 induces CNPase and myelin oligodendrocyte glycoprotein expression in the cerebral cortex of the murine model of cuprizone-induced demyelination.
Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs.
An in vitro micromethod for the quantitative assessment of central demyelination.
Behavioral and neurobiological changes in a novel mouse model of schizophrenia induced by the combination of cuprizone and MK-801.
CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice.
Correlation between 2',3'-cyclic nucleotide 3'-phosphohydrolase activity and demyelination in vitro using a syngeneic system.
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Hexachlorophene and Cuprizone Induce the Spongy Change of the Developing Rat Brain by Different Mechanisms: The Role of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase).
Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse.
Induction of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase in Demyelination of BALB/c Mice Caused by Angiostrongylus cantonensis.
Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions.
Insulin-like growth factor I increases myelination and inhibits demyelination in cultured organotypic nerve tissue.
Mobilization of progenitors in the subventricular zone to undergo oligodendrogenesis in the Theiler's virus model of multiple sclerosis: implications for remyelination at lesions sites.
Myelin-associated changes in mouse brain following irradiation.
Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice.
Primary demyelination induced by exposure to tellurium alters mRNA levels for nerve growth factor receptor, SCIP, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteolipid protein in rat sciatic nerve.
Quantitative chemical analysis of demyelination in cultured mouse spinal cord.
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]
Down Syndrome
Decreased brain levels of 2',3'-cyclic nucleotide-3'-phosphodiesterase in Down syndrome and Alzheimer's disease.
Encephalomyelitis, Autoimmune, Experimental
2',3'-cyclic nucleotide 3'-phosphohydrolase activity in rat visual pathways with experimental allergic encephalomyelitis.
2',3'-Cyclic nucleotide 3'-phosphohydrolase activity of the central nervous tissue in experimental allergic encephalomyelitis.
Changes in cathepsins B-1 and D, neutral proteinase and 2',3'-cyclic nucleotide-3'-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis.
Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice.
Fetal Alcohol Spectrum Disorders
[Activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in the central nervous system of rat fetal alcohol syndrome during development (author's transl)]
Glioblastoma
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival.
Glioma
CD133+ and nestin+ tumor-initiating cells dominate in N29 and N32 experimental gliomas.
Characterization of a cell line derived from a human oligodendroglioma.
Cyclic AMP induction of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase in rat oligodendrocytes.
Increased myelination related enzymatic activities in neuron-glial heterokarya.
Induction of 2',3'-cyclic nucleotide 3'-phosphohydrolase and morphological alterations in C6 glioma cells by dexamethasone, (3-butoxy-4-methoxybenzyl)-2-imidazolinone and prostaglandin E1.
Induction of myelin components: cyclic AMP increases the synthesis rate of 2',3'-cyclic nucleotide 3'-phosphohydrolase in C6 glioma cells.
Intracellular localization of 2',3'-cyclic nucleotide 3'-phosphohydrolase in rat oligodendrocytes and C6 glioma cells, and effect of cell maturation and enzyme induction on localization.
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.
Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation.
Two independent mechanisms of induction of 2':3'-cyclic-nucleotide 3'-phosphohydrolase in glioma cells by cyclic AMP and high cell density.
Goiter
Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog).
Heart Failure
Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility.
Hyperthyroidism
Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system.
Hypothyroidism
Hypothyroidism coordinately and transiently affects myelin protein gene expression in most rat brain regions during postnatal development.
Selective effect of hypothyroidism on expression of myelin markers during development.
Ultrastructural identification of oligodendrocyte/myelin proteins in corpus callosum of hypothyroid animals.
Infarction, Middle Cerebral Artery
Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro.
Infections
Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain.
White matter damage and chemokine induction in developing rat brain after intrauterine infection.
[Intrauterine infection affects early growth and neurobehavioral development in neonatal rats].
Iron Deficiencies
Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats.
Ischemic Stroke
Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination.
Leukemia
Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia.
Malnutrition
Effects of neonatal undernutrition on the lipid composition of gray matter and white matter in rat brain.
Effects of prenatal and neonatal nutritional deficiencies on the 2',3'-cyclic nucleotide-3'-phosphohydrolase activity in the brain and spinal cord of rats.
Meningitis
Abundant extracellular myelin in the meninges of patients with multiple sclerosis.
Menkes Kinky Hair Syndrome
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]
Multiple Sclerosis
2',3'-Cyclic nucleotide 3'-phosphodiesterase activity in the cerebrospinal fluid of patients with demyelinating diseases.
2',3'-Cyclic nucleotide 3'-phosphohydrolase and lipids of myelin from multiple sclerosis and normal brains.
Activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in human cerebrospinal fluid.
Alpha actinin is specifically recognized by Multiple Sclerosis autoantibodies isolated using an N-glucosylated peptide epitope.
Analysis of polymorphisms of the 2',3'-cyclic nucleotide-3'-phosphodiesterase gene in patients with multiple sclerosis.
Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders.
Erythrocyte membrane 2', 3'-cyclic nucleotide 3'-phosphodiesterase activity in multiple sclerosis.
Membrane-bound 2',3',-cyclic nucleotide 3'-phosphohydrolase activity of lymphocytes, granulocytes and erythrocytes in multiple sclerosis.
Reduced 2',3'-cyclic nucleotide 3'-phosphohydrolase activity in erythrocyte membranes of patients with multiple sclerosis.
Simultaneous measurement of 2':3' cyclic-nucleotide 3' phosphodiesterase and RNase activities in sera and spinal fluids of multiple sclerosis patients.
T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients.
The human oligodendrocyte proteome.
Transketolase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients.
Neoplasms
Canine Gliomatosis Cerebri: Morphologic and Immunohistochemical Characterization Is Supportive of Glial Histogenesis.
Demyelination induced by protein kinase C-activating tumor promoters in aggregating brain cell cultures.
Ependymoma in a dwarf goat.
Histologic and Immunohistochemical Classification of 41 Bovine Adrenal Gland Neoplasms.
Immunohistochemistry for 2',3'-Cyclic Nucleotide-3'-Phosphohydrolase in 63 Bovine Peripheral Nerve Sheath Tumors.
Malignant peripheral nerve sheath tumour in the nasopharynx of a cow.
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.
Sox21 inhibits glioma progression in vivo by forming complexes with Sox2 and stimulating aberrant differentiation.
Nerve Sheath Neoplasms
Immunohistochemistry for 2',3'-Cyclic Nucleotide-3'-Phosphohydrolase in 63 Bovine Peripheral Nerve Sheath Tumors.
Neurilemmoma
Histologic and Immunohistochemical Classification of 41 Bovine Adrenal Gland Neoplasms.
Neuroblastoma
Differential expression of 2':3'-cyclic nucleotide 3'-phosphodiesterase in cultured central, peripheral, and extraneural cells.
Increased myelination related enzymatic activities in neuron-glial heterokarya.
Neurofibroma
Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.
Newcastle Disease
Localization of 2',3'-decycling phosphodiesterases in the Newcastle disease virus virion.
Oligodendroglioma
An immunochemical investigation of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP) in bovine cerebrum and human oligodendroglioma.
Differential expression of 2':3'-cyclic nucleotide 3'-phosphodiesterase in cultured central, peripheral, and extraneural cells.
Expression of oligodendrocyte-associated genes in cell lines derived from human gliomas and neuroblastomas.
Optic Nerve Diseases
2',3'-Cyclic nucleotide 3'-phosphohydrolase in acrylamide-induced optic neuropathy in rabbit.
Paralysis
Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs.
Immunosuppressive effect of gramicidin S on experimental ocular neuritis and allergic encephalomyelitis.
Peripheral Nervous System Diseases
Regulation of 2',3'-cyclic nucleotide phosphodiesterase gene expression in experimental peripheral neuropathies.
Respiratory Insufficiency
The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in the corpus callosum, subcortical white matter, and spinal cord in infants dying from sudden infant death syndrome.
Rett Syndrome
Downregulation of CNPase in a MeCP2 deficient mouse model of Rett syndrome.
Sarcoma
Malignant peripheral nerve sheath tumour in the nasopharynx of a cow.
Spinal Cord Injuries
[Protective effect of transplantation of bone mesenchymal stem cells on demyelination in spinal cord injury].
Stroke
Abundant extracellular myelin in the meninges of patients with multiple sclerosis.
Tremor
Lipid composition of myelin and protein--lipid complex in a neurological rabbit mutant.