3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

This is an abbreviated version!
For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Reaction

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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Results	in table
35	Activating Compound
1145	AA Sequence
7	Application
1	CAS Registry Number
27	Cloned(Commentary)
8	Crystallization (Commentary)
284	Disease/ Diagnostics
11	Expression
39	General Information
8	General Stability
117	Inhibitors
19	kcat/KM [mM/s]
6	Ki Value [mM]
112	KM Value [mM]
72	Localization
37	Metals/Ions
72	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
631	Organism
38	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
3	pI Value
14	Posttranslational Modification
73	Protein Variants
22	Purification (Commentary)
4	Reaction
2	Reaction Type
136	Reference
287	Source Tissue
58	Specific Activity [micromol/min/mg]
10	Storage Stability
268	Substrates and Products (Substrate)
49	Subunits
102	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
72	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

7.63 - 118

2',3'-cAMP

2 entries

1.97

2',3'-cGMP

Escherichia coli

P06961

+/- 0.08

652555

1.15 - 1690

2',3'-cNADP

20 entries

14 - 1420

2',3'-cNADP+

13 entries

14 - 940

2',3'-Cyclic AMP

5 entries

3.09

2'-AMP

Escherichia coli

P06961

+/- 0.14

652555

1.24

ADP

Escherichia coli

P06961

+/- 0.07

652555

3.78

ATP

Escherichia coli

P06961

+/- 0.12

652555

4.83

CDP

Escherichia coli

P06961

+/- 0.39

652555

3.36

CTP

Escherichia coli

P06961

+/- 0.17

652555

0.031 - 34.3

cyclic 2',3'-AMP

20 entries

1.97 - 2.94

cyclic 2',3'-GMP

2 entries

2.51

diphosphate

Escherichia coli

P06961

+/- 0.05

652555

14.9

NADP

Escherichia coli

P06961

+/- 0.5

652555

10.3

p-nitrophenyl phosphate

Escherichia coli

P06961

+/- 0.28

652555

additional information

additional information

Bos taurus

-

-

135388

-

7.63

2',3'-cAMP

Escherichia coli

P06961

+/- 0.48

652555

118

2',3'-cAMP

Mus musculus

-

full-length protein

707896

1.15

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H230F mutant CNP1

652106

1.16

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H230L mutant CNP1

652106

1.27

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H309L mutant CNP1

652106

1.35

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H309F mutant CNP1

652106

6.08

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H230L mutant CNP1

652106

6.08

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H309L mutant CNP1

652106

594

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C314S mutant CNP1

652106

825

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C231S mutant CNP1

652106

968

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C231A mutant CNP1

652106

1107

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236S mutant CNP1

652106

1110

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236S mutant CNP1

652106

1116

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C314A mutant CNP1

652106

1120

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C314A mutant CNP1

652106

1130

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C397S mutant CNP1

652106

1132

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C397S mutant CNP1

652106

1195

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, recombinant full-length wild-type CNP1

652106

1200

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, recombinant full-length wild-type CNP1

652106

1476

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236A mutant CNP1

652106

1480

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236A mutant CNP1

652106

1690

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, catalytic fragment of CNP1 corresponding to the C-terminal 250 amino acids

652106

14

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H230S, pH and temperature not specified in the publication

752180

21

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H309S, pH and temperature not specified in the publication

752180

24

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H230Q, pH and temperature not specified in the publication

752180

183

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme F235A, pH and temperature not specified in the publication

752180

221

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme F235L, pH and temperature not specified in the publication

752180

231

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme T232A, pH and temperature not specified in the publication

752180

237

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme Y168A, pH and temperature not specified in the publication

752180

732

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme V321A, pH and temperature not specified in the publication

752180

887

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme Y168S, pH and temperature not specified in the publication

752180

940

2',3'-cNADP+

Mus musculus

P16330

wild type enzyme, pH and temperature not specified in the publication

752180

1182

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme R307Q, pH and temperature not specified in the publication

752180

1332

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme P296G, pH and temperature not specified in the publication

752180

1420

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme P225G, pH and temperature not specified in the publication

752180

14

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H230S, pH and temperature not specified in the publication

730215

21

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H309S, pH and temperature not specified in the publication

730215

24

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H230Q, pH and temperature not specified in the publication

730215

732

2',3'-Cyclic AMP

Mus musculus

P16330

mutant V321A, pH and temperature not specified in the publication

730215

940

2',3'-Cyclic AMP

Mus musculus

P16330

wild-type enzyme, pH and temperature not specified in the publication

730215

0.031 - 0.51

cyclic 2',3'-AMP

Escherichia coli

P06961

pH 7, 37°C

652555

1.45

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189A, pH 7.5, 45°C

682186

1.8

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392A, pH 7.5, 45°C

682186

3.2

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H376D, pH 7.5, 45°C

682186

3.25

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D233E, pH 7.5, 45°C

682186

4.5

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236A, pH 7.5, 45°C

682186

5.1

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H376N, pH 7.5, 45°C

682186

5.8

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236N, pH 7.5, 45°C

682186

6

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236E, pH 7.5, 45°C

682186

6.5

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H323Q, pH 7.5, 45°C

682186

7.63

cyclic 2',3'-AMP

Escherichia coli

P06961

pH 7, 37°C

652555

8.6

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237A, pH 7.5, 45°C

682186

8.9

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

wild-type, pH 7.5, 45°C

682186

9.1

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H323A, pH 7.5, 45°C

682186

15.9

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392E, pH 7.5, 45°C

682186

17.2

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189E, pH 7.5, 45°C

682186

18.7

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392N, pH 7.5, 45°C

682186

20.2

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237Q, pH 7.5, 45°C

682186

26.2

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237K, pH 7.5, 45°C

682186

34.3

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189D, pH 7.5, 45°C

682186

1.97

cyclic 2',3'-GMP

Escherichia coli

P06961

pH 7, 37°C

652555

2.94

cyclic 2',3'-GMP

Escherichia coli

P06961

pH 7, 37°C

652555