EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
significantly decreased levels of FDH and its mRNA in 15 tested tumors compared with normal tissues, strong down-regulation of FDH on both the mRNA and protein level in tumors |
392350 |
2.3.1.57 | diamine N-acetyltransferase |
A-549 cell |
lung-cancer derived cells |
487265 |
2.7.7.15 | choline-phosphate cytidylyltransferase |
A-549 cell |
- |
642902 |
2.7.4.14 | UMP/CMP kinase |
A-549 cell |
lung carcinoma |
645160 |
6.1.1.20 | phenylalanine-tRNA ligase |
A-549 cell |
lung carcinoma cell line |
649540 |
3.4.24.B7 | matrix metalloproteinase-26 |
A-549 cell |
lung carcinoma, gene expression |
650768 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
A-549 cell |
0.7% of the activity in liver |
655483 |
3.6.1.13 | ADP-ribose diphosphatase |
A-549 cell |
- |
655991 |
1.2.1.36 | retinal dehydrogenase |
A-549 cell |
lung cancer |
656611 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
inducible expression of 10-formyltetrahydrofolate dehydrogenase |
656770 |
3.2.2.5 | NAD+ glycohydrolase |
A-549 cell |
lung epithelial cell line |
656778 |
2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
A-549 cell |
- |
658123 |
2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
A-549 cell |
low activity |
658123 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
A-549 cell |
- |
658123 |
2.4.1.90 | N-acetyllactosamine synthase |
A-549 cell |
lung carcinoma cell line |
658123 |
1.8.1.9 | thioredoxin-disulfide reductase |
A-549 cell |
- |
658795, 685557, 698054, 712072 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
A-549 cell |
lung cancer cell line |
659317 |
1.8.98.2 | sulfiredoxin |
A-549 cell |
- |
659421, 698052, 698928, 698993, 700520, 725510 |
1.7.1.7 | GMP reductase |
A-549 cell |
- |
659550 |
2.5.1.75 | tRNA dimethylallyltransferase |
A-549 cell |
- |
660041 |
2.4.1.18 | 1,4-alpha-glucan branching enzyme |
A-549 cell |
- |
660544 |
1.11.1.6 | catalase |
A-549 cell |
- |
660661 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
A-549 cell |
Pseudomonas aeruginosa stimulates expression of inducible nitric oxide synthase by A-549 cells |
660685 |
2.7.1.30 | glycerol kinase |
A-549 cell |
lung cell line |
660906 |
2.7.11.21 | polo kinase |
A-549 cell |
- |
661663, 702558 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
A-549 cell |
- |
662925, 678594, 691220, 702620, 705649, 716400, 727171, 747038, 747701, 750475 |
2.7.10.2 | non-specific protein-tyrosine kinase |
A-549 cell |
epithelial lung cell line |
663436 |
3.4.21.68 | t-Plasminogen activator |
A-549 cell |
- |
663857 |
3.4.22.55 | caspase-2 |
A-549 cell |
human lung adenocarcinoma cell |
665247 |
3.1.3.16 | protein-serine/threonine phosphatase |
A-549 cell |
the enzyme activity is increased in long-term hypoxia |
665578 |
3.4.11.1 | leucyl aminopeptidase |
A-549 cell |
- |
665925 |
1.1.1.21 | aldose reductase |
A-549 cell |
type II alveolar epithelial cell line, AR expression analysis |
667420 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
lung adenocarcinoma cell line |
667558, 668173 |
5.3.99.3 | prostaglandin-E synthase |
A-549 cell |
- |
667959, 678094, 690622, 693577, 693823, 706521, 714421, 714468, 715856, 715865, 748441, 748846 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
- |
668172, 685958, 689069, 695883, 740148, 740159 |
1.1.1.21 | aldose reductase |
A-549 cell |
lung adenocarcinoma cell line |
668222 |
3.4.21.73 | u-Plasminogen activator |
A-549 cell |
A-549 alveolar epithelial cell cultured on a fibrin matrix, stimulation by interleukin 1beta results in increased levels of enzyme in culture supernatant |
670938 |
3.4.21.B6 | prostasin |
A-549 cell |
- |
671251 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
- |
671840, 713003 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
A-549 cell |
lung adenocarcinoma cells |
672316 |
2.7.1.74 | deoxycytidine kinase |
A-549 cell |
- |
672797 |
2.3.3.8 | ATP citrate synthase |
A-549 cell |
- |
672878, 735620, 756645 |
2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase |
A-549 cell |
- |
672911 |
2.7.1.78 | polynucleotide 5'-hydroxyl-kinase |
A-549 cell |
- |
672918, 703029, 704680 |
2.7.1.138 | ceramide kinase |
A-549 cell |
- |
673703, 675274, 691938 |
2.7.1.138 | ceramide kinase |
A-549 cell |
human lung adenocarcinoma cell |
673703 |
2.5.1.6 | methionine adenosyltransferase |
A-549 cell |
- |
673793 |
2.3.1.57 | diamine N-acetyltransferase |
A-549 cell |
TNFalpha can lead to the induction of NFkappaB signaling with a concomitant increase in spermidine/spermine N1-acetyltransferase expression |
674623 |
2.3.1.48 | histone acetyltransferase |
A-549 cell |
- |
675963, 703846, 736413 |
3.4.21.B26 | proprotein convertase 5 |
A-549 cell |
- |
675967 |
4.1.1.17 | ornithine decarboxylase |
A-549 cell |
lung cancer cell line |
677292 |
3.4.22.57 | caspase-4 |
A-549 cell |
- |
677484 |
2.7.12.2 | mitogen-activated protein kinase kinase |
A-549 cell |
- |
679153, 705707 |
2.7.12.2 | mitogen-activated protein kinase kinase |
A-549 cell |
human alveolar Type II epithelial adenocarcinoma cell line |
679153 |
3.1.4.12 | sphingomyelin phosphodiesterase |
A-549 cell |
- |
679685, 694260 |
3.1.3.4 | phosphatidate phosphatase |
A-549 cell |
- |
679998 |
3.6.1.75 | diacylglycerol diphosphate phosphatase |
A-549 cell |
- |
679998 |
3.4.22.52 | calpain-1 |
A-549 cell |
protein phosphatase 2A functions as a physiological calpain phosphatase to directly dephosphorylate mu-calpain, which leads to decreased calpain activity and suppression of migration and invasion of human lung cancer cells |
680713 |
3.1.4.12 | sphingomyelin phosphodiesterase |
A-549 cell |
epithelial cell |
680767 |
4.1.1.17 | ornithine decarboxylase |
A-549 cell |
lung carcinoma cells |
681869 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
A-549 cell |
- |
681872 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
A-549 cell |
- |
681923, 708461 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
A-549 cell |
lung epithelial cell |
682912 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
A-549 cell |
lung epithelial cell |
682912 |
3.4.21.109 | matriptase |
A-549 cell |
- |
683364 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
A-549 cell |
- |
685023 |
1.17.4.2 | ribonucleoside-triphosphate reductase (thioredoxin) |
A-549 cell |
- |
685023 |
2.3.1.37 | 5-aminolevulinate synthase |
A-549 cell |
sodium butyrate treatment activates ALAS2 gene transcription |
685795 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
A-549 cell |
lung cancer cell line A549. After mechanical damage, TGase 2 appears to contribute to membrane resealing |
685996 |
2.5.1.18 | glutathione transferase |
A-549 cell |
- |
687298 |
3.4.22.55 | caspase-2 |
A-549 cell |
expression of c-Myc and caspase-2 are crucial for cytochrome c release from mitochondria during cytotoxic stress. Caspase-2 is important for cytosolic Bax to integrate into the outer mitochondrial membrane |
687708 |
1.8.1.9 | thioredoxin-disulfide reductase |
A-549 cell |
TXNRD1_v3 is induced by estradiol or testosterone treatments |
687762 |
3.6.5.2 | small monomeric GTPase |
A-549 cell |
- |
687915 |
3.4.21.7 | plasmin |
A-549 cell |
plasmin is generated by the plasmin/u-PA system on surfaces of A-549 alveolar lining cells |
688780 |
1.5.99.B2 | proline dehydrogenase (acceptor) |
A-549 cell |
- |
689071 |
2.4.2.4 | thymidine phosphorylase |
A-549 cell |
- |
689244 |
1.8.1.9 | thioredoxin-disulfide reductase |
A-549 cell |
human lung non-small cell carcinoma |
689708 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
up-regulation of cyclooxygenase-2 expression by pro-inflammatory cytokines is accompanied by down-regluation of 15-hydroxyprostaglandin dehydrogenase expression. Over-expression of cyclooxygenase-2 but not -1 also attenuates 15-hydroxyprostaglandin dehydrogenase expression. Similarly, overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits interleukin 1beta-induced cyclooxygenase-2 expression and results in apoptosis. The levels of 15-hydroxyprostaglandin dehydrogenase expression in transfected cells correlate positively with those of mesenchymal markers, and negatively with those of epithelial markers |
689843 |
1.5.3.16 | spermine oxidase |
A-549 cell |
- |
690802, 765148 |
2.7.11.22 | cyclin-dependent kinase |
A-549 cell |
- |
691272, 737959, 760304 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
- |
691321, 691729, 702564, 702620, 705047, 714463, 727417, 747038, 747693, 747698 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
lung cancer cell |
691619 |
6.3.2.17 | tetrahydrofolate synthase |
A-549 cell |
- |
691823 |
6.1.1.4 | leucine-tRNA ligase |
A-549 cell |
LARS1 is over-expressed in lung cancer cell line A549 |
692229 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
A-549 cell |
- |
692332 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
A-549 cell |
- |
692674, 694350, 711167, 713005, 744505, 745830 |
3.1.4.11 | phosphoinositide phospholipase C |
A-549 cell |
- |
692686, 694785 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
human lung cancer cells |
693067 |
4.1.1.84 | D-dopachrome decarboxylase |
A-549 cell |
lung adenocarcinoma cell line |
693465 |
3.2.1.14 | chitinase |
A-549 cell |
- |
693471 |
2.7.11.24 | mitogen-activated protein kinase |
A-549 cell |
human lung epithelial cell line |
693505 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
nonsmall cell lung cancer cell line |
693543 |
2.7.1.138 | ceramide kinase |
A-549 cell |
ceramide kinase amplified from an A549 cDNA library |
694006 |
4.6.1.2 | guanylate cyclase |
A-549 cell |
- |
694121 |
2.7.10.2 | non-specific protein-tyrosine kinase |
A-549 cell |
- |
694492, 762522 |
3.5.1.98 | histone deacetylase |
A-549 cell |
- |
695508, 696050, 696610, 699429, 704641, 711088, 712434 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
A-549 cell |
- |
695513 |
1.6.5.10 | NADPH dehydrogenase (quinone) |
A-549 cell |
- |
696015 |
4.2.1.3 | aconitate hydratase |
A-549 cell |
- |
696168 |
3.4.22.61 | caspase-8 |
A-549 cell |
- |
697284, 698258, 708818 |