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Literature summary for 1.8.1.9 extracted from

  • Dammeyer, P.; Damdimopoulos, A.E.; Nordman, T.; Jimenez, A.; Miranda-Vizuete, A.; Arner, E.S.
    Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1 (2008), J. Biol. Chem., 283, 2814-2821.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the Grx domain of TXNRD1_v3 localizes first in the emerging protrusion and is then followed into the protrusions by actin and subsequently by tubulin. TXNRD1_v3 can guide actin polymerization in relation to cell membrane restructuring Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q16881
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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HCC-1937 cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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heart transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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HeLa cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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kidney transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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Leydig cell TXNRD1_v3 is predominantly expressed in the Leydig cells Homo sapiens
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liver transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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NCI-H157 cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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NCI-H23 cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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ovary transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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pancreas transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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spleen transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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testis transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas Homo sapiens
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U-1810 cell TXNRD1_v3 is induced by estradiol or testosterone treatments Homo sapiens
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Synonyms

Synonyms Comment Organism
thioredoxin reductase 1
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Homo sapiens
TrxR1
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Homo sapiens