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Literature summary for 1.2.1.36 extracted from

  • Moreb, J.S.; Gabr, A.; Vartikar, G.R.; Gowda, S.; Zucali, J.R.; Mohuczy, D.
    Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde (2005), J. Pharmacol. Exp. Ther., 312, 339-345.
    View publication on PubMed
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Application

Application Comment Organism
medicine retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde in lung cancer cell lines Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Homo sapiens
-
 retinoate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell lung cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Homo sapiens retinoate + NADH
-
 ?

Synonyms

Synonyms Comment Organism
ALDH-1A1 ambiguous Homo sapiens
ALDH-3A1 ambiguous Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens