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Literature summary for 2.7.7.15 extracted from

  • Weinhold, P.A.; Rounsifer, M.E.; Charles, L.; Feldman, D.A.
    Characterization of cytosolic forms of CTP:choline-phosphate cytidylyltransferase in lung, isolated alveolar type II cells, A549 cell and Hep G2 cells (1989), Biochim. Biophys. Acta, 1006, 299-310.
    View publication on PubMed
Search for more literature for 2.7.7.15

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 2 * 45000, Hep G2 cells, L-form of enzyme, SDS-PAGE Rattus norvegicus
284000
-
 Hep G2 cells, H-form of enzyme, glycerol density gradient centrifugation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus H-form is the active form of enzyme in cytoplasm ?
-
 ?
additional information Rattus norvegicus change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein H-form appears to be a lipoprotein consisting of an apoprotein i.e. L-form dimer of 45000 MW subunits complexed with lipids Rattus norvegicus
lipoprotein H-form of enzyme Rattus norvegicus
lipoprotein phosphatidylinositol is present in the H-form isolated from Hep G2 cells Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
alveolar cell type II cell, L- and H-form Rattus norvegicus
-
Hep-G2 cell L-form and H-form Homo sapiens
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
lung
-
 Homo sapiens
-
lung L-form and H-form Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
 Homo sapiens diphosphate + CDPcholine
-
 ?
CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?
additional information H-form is the active form of enzyme in cytoplasm Rattus norvegicus ?
-
 ?
additional information change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 45000, Hep G2 cells, L-form of enzyme, SDS-PAGE Rattus norvegicus