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ATP + (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine
ADP + (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine
Cidofovir
-
-
?
ATP + 1-beta-D-arabinofuranosylcytosine
ADP + ?
-
-
-
?
ATP + 2',2'-difluorodeoxycytidine
ADP + ?
-
-
-
?
ATP + 2'-azido-CMP
ADP + 2'-azido-CDP
-
4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP
-
-
?
ATP + 2'-azido-D-dCMP
ADP + 2'-azido-D-dCDP
-
-
-
-
?
ATP + 2'-azido-D-dUMP
ADP + 2'-azido-D-dUDP
-
-
-
-
?
ATP + 2'-azido-dCMP
ADP + 2'-azido-dCDP
-
4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP
-
-
?
ATP + 2'-azido-dUMP
ADP + 2'-azido-dUDP
-
similar activity with 2'-azido-UMP and 2'-azido-dUMP
-
-
?
ATP + 2'-azido-L-dCMP
ADP + 2'-azido-L-dCDP
-
-
-
-
?
ATP + 2'-azido-L-dUMP
ADP + 2'-azido-L-dUDP
-
-
-
-
?
ATP + 2'-azido-UMP
ADP + 2'-azido-UDP
-
similar activity with 2'-azido-UMP and 2'-azido-dUMP
-
-
?
ATP + 5-aza-cidofovir
ADP + phospho-5-aza-cidofovir
ATP + ara-CMP
ADP + ara-CDP
ATP + beta-D-2',3'-dideoxy-CMP + H2O
ADP + ?
-
-
-
-
?
ATP + beta-D-2'-azido-2'-dCMP
ADP + beta-D-2'-azido-2'-dCDP
-
-
-
?
ATP + beta-D-2'-azido-2'-dUMP
ADP + beta-D-2'-azido-2'-dUDP
-
-
-
?
ATP + beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CMP
ADP + ?
-
-
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine diphosphate
-
-
-
-
?
ATP + beta-L-2',3'-dideoxy-CMP + H2O
ADP + ?
-
-
-
-
?
ATP + beta-L-2'-azido-2'-dCMP
ADP + beta-L-2'-azido-2'-dCDP
-
-
-
?
ATP + beta-L-2'-azido-2'-dUMP
ADP + beta-L-2'-azido-2'-dUDP
-
-
-
?
ATP + beta-L-dioxolane-cytidine
ADP + ?
-
-
-
-
?
ATP + cidofovir
ADP + phospho-cidofovir
ATP + cytarabine
ADP + phospho-cytarabine
ATP + D-CMP
ADP + D-CDP
-
-
-
?
ATP + D-dCMP
ADP + D-dCDP
-
-
-
?
ATP + D-dUMP
ADP + D-dUDP
-
-
-
?
ATP + D-UMP
ADP + D-UDP
-
-
-
?
ATP + dAMP
ADP + dADP
-
-
-
?
ATP + gemcitabine
ADP + gemcitabine monophosphate
activity of DCK
i.e. 2',2'-difluorodeoxycytidine 5'-monophosphate
-
?
ATP + gemcitabine
ADP + phospho-gemcitabine
ATP + gemcitabine monophosphate
ADP + ?
-
-
-
-
?
ATP + gemcitabine phosphate
ADP + gemcitabine diphosphate
activity of CMPK
i.e. 2',2'-difluorodeoxycytidine 5'-diphosphate
-
?
ATP + L-(-)-2',3'-dideoxy-3'-thia-CMP
ADP + L-(-)-2',3'-dideoxy-3'-thia-CDP
ATP + L-(-)-2',3'-dideoxy-5-fluoro-3'-thia-CMP
ADP + ?
-
-
-
-
?
ATP + L-3TCMP
ADP + L-3TCMP
-
-
-
?
ATP + L-dCMP
ADP + L-dCDP
ATP + L-dUMP
ADP + L-dUDP
dATP + dCMP
dADP + dCDP
-
-
-
-
?
dCTP + CMP
dCDP + CDP
-
-
-
-
?
dCTP + dCMP
dCDP + dCDP
-
-
-
-
?
dCTP + UMP
dGDP + UDP
-
-
-
-
?
dGTP + UMP
dGDP + UDP
-
-
-
-
?
dTTP + CMP
dTDP + CDP
-
-
-
-
?
dUTP + CMP
dUDP + CDP
-
-
-
-
?
GTP + dCMP
GDP + dCDP
-
-
-
-
?
GTP + UMP
GDP + UDP
-
-
-
-
?
ITP + CMP
IDP + CDP
-
-
-
-
?
ITP + UMP
IDP + UDP
-
-
-
-
?
TTP + CMP
TDP + CDP
-
-
-
-
?
TTP + dCMP
TDP + dCMP
-
-
-
-
?
TTP + UMP
TDP + UDP
-
-
-
-
?
UTP + CMP
UDP + CDP
-
-
-
-
?
XTP + CMP
XDP + CDP
-
-
-
-
?
additional information
?
-
ATP + 5-aza-cidofovir
ADP + phospho-5-aza-cidofovir
-
-
-
?
ATP + 5-aza-cidofovir
ADP + phospho-5-aza-cidofovir
wild-type enzyme
-
-
?
ATP + AMP
ADP + ADP
-
-
-
-
r
ATP + AMP
ADP + ADP
-
-
-
r
ATP + ara-CMP
ADP + ara-CDP
-
-
-
-
?
ATP + ara-CMP
ADP + ara-CDP
-
-
-
-
?
ATP + ara-CMP
ADP + ara-CDP
-
-
-
?
ATP + cidofovir
ADP + phospho-cidofovir
i.e. (S)-[1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxy-methylphosphonic acid
-
-
?
ATP + cidofovir
ADP + phospho-cidofovir
i.e. (S)-[1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxy-methylphosphonic acid, wild-type enzyme
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
r
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
low activity
-
-
?
ATP + CMP
ADP + CDP
preferred substrate
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme is required during rapid cell growth
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
ATP + CMP
ADP + CDP
wild-type enzyme and mutant P64T
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + cytarabine
ADP + phospho-cytarabine
anticancer drug, phosphorylation catalyzed by the enzyme in cidofovir-resistant HaCaT cells
-
-
?
ATP + cytarabine
ADP + phospho-cytarabine
i.e. araC, wild-type enzyme and mutant P64T
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dCMP
ADP + dCDP
high activity
-
-
?
ATP + dCMP
ADP + dCDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + dCMP
ADP + dCDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
ATP + dCMP
ADP + dCDP
-
higher activity with the D-enantiomer compared to the L-enantiomer
-
-
?
ATP + dCMP
ADP + dCDP
wild-type enzyme and mutant P64T
-
-
?
ATP + dCMP
ADP + dCDP
-
no evidence for reversal of the reaction
-
?, ir
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
-
?
ATP + dUMP
ADP + dUDP
-
-
-
-
?
ATP + dUMP
ADP + dUDP
-
-
-
-
?
ATP + dUMP
ADP + dUDP
-
-
-
?
ATP + dUMP
ADP + dUDP
best substrate
-
-
?
ATP + dUMP
ADP + dUDP
wild-type enzyme
-
-
?
ATP + dUMP
ADP + dUDP
no activity with CDP, dTMP, AMP, GMP
-
-
?
ATP + dUMP
ADP + dUDP
-
higher activity with the D-enantiomer compared to the L-enantiomer
-
-
?
ATP + dUMP
ADP + dUDP
-
-
-
-
?
ATP + gemcitabine
ADP + phospho-gemcitabine
i.e. 2',2'-difluorodeoxycytidine
-
-
?
ATP + gemcitabine
ADP + phospho-gemcitabine
i.e. 2',2'-difluorodeoxycytidine, wild-type enzyme
-
-
?
ATP + L-(-)-2',3'-dideoxy-3'-thia-CMP
ADP + L-(-)-2',3'-dideoxy-3'-thia-CDP
-
-
-
-
?
ATP + L-(-)-2',3'-dideoxy-3'-thia-CMP
ADP + L-(-)-2',3'-dideoxy-3'-thia-CDP
-
-
-
-
?
ATP + L-CMP
ADP + L-CDP
-
-
-
-
?
ATP + L-CMP
ADP + L-CDP
poor substrate
-
-
?
ATP + L-dCMP
ADP + L-dCDP
-
-
-
-
?
ATP + L-dCMP
ADP + L-dCDP
slower phosphorylation than the D-enantiomers
-
-
?
ATP + L-dUMP
ADP + L-dUDP
-
-
-
-
?
ATP + L-dUMP
ADP + L-dUDP
slower phosphorylation than the D-enantiomers
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
r
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
low activity
-
-
?
ATP + UMP
ADP + UDP
preferred substrate
-
-
?
ATP + UMP
ADP + UDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + UMP
ADP + UDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
ATP + UMP
ADP + UDP
wild-type enzyme and mutant P64T
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
CTP + CMP
CDP + CDP
-
-
-
-
?
CTP + CMP
CDP + CDP
-
-
-
-
?
dATP + CMP
dADP + CDP
-
-
-
-
?
dATP + CMP
dADP + CDP
-
-
-
-
?
dATP + UMP
dADP + ADP
-
-
-
-
?
dATP + UMP
dADP + ADP
-
-
-
-
r
dATP + UMP
dADP + ADP
-
-
-
-
?
dATP + UMP
dADP + ADP
-
dATP shows 10% of the activity with ATP
-
-
?
dGTP + CMP
dGDP + CDP
-
-
-
-
?
dGTP + CMP
dGDP + CDP
-
-
-
-
?
GTP + CMP
GDP + CDP
-
-
-
-
?
GTP + CMP
GDP + CDP
-
-
-
-
?
additional information
?
-
-
formation of a ternary complex, addition of substrates is random
-
-
?
additional information
?
-
-
the UMP-CMP kinase has a relaxed enantiospecificity for the nucleoside monophosphate acceptor site, but it is restricted to D-nucleotides at the donor site
-
-
?
additional information
?
-
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
-
-
?
additional information
?
-
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response
-
-
?
additional information
?
-
-
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response
-
-
?
additional information
?
-
substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview
-
-
?
additional information
?
-
-
substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview
-
-
?
additional information
?
-
-
the enzyme shows enantioselectivity, acceptor-binding site structure of human UMP-CMP kinase in the closed form or in ligand-bound forms, overview
-
-
?
additional information
?
-
hyperensitivity and resistance against anti-cancer drugs in the different cervical tumour cell lines, effects of changes on UMP/CMPK1 expression on CTP and UTP synthesis , overview
-
-
?
additional information
?
-
CMP and UMP are the preferred substrates for purified CMPK, and it has lower affinity to dCMP and dUMP
-
-
?
additional information
?
-
mutants P64T/R134M and R134M show no activity with all substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 5-aza-cidofovir
ADP + phospho-5-aza-cidofovir
-
-
-
?
ATP + cidofovir
ADP + phospho-cidofovir
i.e. (S)-[1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxy-methylphosphonic acid
-
-
?
ATP + cytarabine
ADP + phospho-cytarabine
anticancer drug, phosphorylation catalyzed by the enzyme in cidofovir-resistant HaCaT cells
-
-
?
ATP + gemcitabine
ADP + phospho-gemcitabine
i.e. 2',2'-difluorodeoxycytidine
-
-
?
additional information
?
-
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
?
ATP + CMP
ADP + CDP
-
-
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme is required during rapid cell growth
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + CMP
ADP + CDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
ATP + dCMP
ADP + dCDP
-
-
-
?
ATP + dCMP
ADP + dCDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + dCMP
ADP + dCDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
ATP + dCMP
ADP + dCDP
-
higher activity with the D-enantiomer compared to the L-enantiomer
-
-
?
ATP + dUMP
ADP + dUDP
-
-
-
?
ATP + dUMP
ADP + dUDP
-
higher activity with the D-enantiomer compared to the L-enantiomer
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
-
-
-
-
?
ATP + UMP
ADP + UDP
-
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis
-
-
?
ATP + UMP
ADP + UDP
-
the enzyme catalyses an important step in the phosphorylation of UTP, CTP and cCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies
-
-
?
additional information
?
-
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
-
-
?
additional information
?
-
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response
-
-
?
additional information
?
-
-
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response
-
-
?
additional information
?
-
hyperensitivity and resistance against anti-cancer drugs in the different cervical tumour cell lines, effects of changes on UMP/CMPK1 expression on CTP and UTP synthesis , overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5'-nucleotidase deficiency
Pyrimidine nucleoside monophosphate kinase hyperactivity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.
Abortion, Missed
Pigment epithelium?derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2: A potential treatment strategy for missed abortion.
Acquired Immunodeficiency Syndrome
Substrate-induced conformational changes in human UMP/CMP kinase.
Acute Lung Injury
MiR-494-3p alleviates acute lung injury through regulating NLRP3 activation by targeting CMPK2.
Atherosclerosis
Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
Bacterial Infections
CMPK2 of triploid crucian carp is involved in immune defense against bacterial infection.
Breast Neoplasms
Potential role of CMPK1, SLC29A1, and TLE4 polymorphisms in gemcitabine-based chemotherapy in HER2-negative metastatic breast cancer patients: pharmacogenetic study results from the prospective randomized phase II study of eribulin plus gemcitabine versus paclitaxel plus gemcitabine (KCSG-BR-13-11).
Breast Neoplasms
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Carcinoma, Hepatocellular
Differences between pyrimidine nucleoside monophosphate kinase from rat Novikoff ascites hepatoma and rat liver.
Carcinoma, Hepatocellular
Pyrimidine nucleoside monophosphate kinase from rat liver and rat Novikoff ascites hepatoma (EC 2.7.4.14).
Carcinoma, Non-Small-Cell Lung
Differential Effect of Polymorphisms of CMPK1 and RRM1 on Survival in Advanced Non-small Cell Lung Cancer Patients Treated with Gemcitabine or Taxane/Cisplatinum.
Carcinoma, Ovarian Epithelial
Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer.
Colorectal Neoplasms
Long noncoding RNA CMPK2 promotes colorectal cancer progression by activating the FUBP3-c-Myc axis.
Hepatitis B, Chronic
MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B.
Infections
Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection.
Infections
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells.
Infections
Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection.
Infections
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
Influenza, Human
Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection.
Leukemia
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Lung Neoplasms
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.
Lung Neoplasms
Differential Effect of Polymorphisms of CMPK1 and RRM1 on Survival in Advanced Non-small Cell Lung Cancer Patients Treated with Gemcitabine or Taxane/Cisplatinum.
Multiple Sclerosis
Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS.
Myopia
Corneal curvature-associated MTOR variant differentiates mild myopia from high myopia in Han Chinese population.
Neoplasm Metastasis
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Neoplasms
Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Neoplasms
Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer.
Neoplasms
Differences between pyrimidine nucleoside monophosphate kinase from rat Novikoff ascites hepatoma and rat liver.
Neoplasms
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Neoplasms
Long intracellular retention of 4'-thio-arabinofuranosylcytosine 5'-triphosphate as a critical factor for the anti-solid tumor activity of 4'-thio-arabinofuranosylcytosine.
Neoplasms
Micropreparative immobilized pH gradient two-dimensional electrophoresis in combination with protein microsequencing for the analysis of human liver proteins.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Staphylococcal Infections
A Novel Peptide Nucleic Acid against the Cytidine Monophosphate Kinase of S. aureus Inhibits Staphylococcal Infection In Vivo.
Stomach Neoplasms
CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer.
Stroke
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Triple Negative Breast Neoplasms
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Tuberculosis
Insight from the structural molecular model of cytidylate kinase from Mycobacterium tuberculosis.
Tuberculosis
Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.
Tuberculosis
Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target.
Tuberculosis
The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
ump/cmp kinase deficiency
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
Viremia
Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection.
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0.45
2',2'-difluorodeoxycytidine
pH 8.0, 37°C
0.36
2'-azido-D-dCMP
-
pH 7.4, 37°C
0.9
2'-azido-D-dUMP
-
pH 7.4, 37°C
1.2
2'-azido-L-dCMP
-
pH 7.4, 37°C
1.3
2'-azido-L-dUMP
-
pH 7.4, 37°C
2.08
5-aza-cidofovir
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.272 - 1.037
beta-D-2',3'-dideoxy-CMP
0.36
beta-D-2'-azido-2'-dCMP
-
0.9
beta-D-2'-azido-2'-dUMP
-
0.228
beta-L-(-)-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CMP
-
37°C
0.15 - 2
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
0.697
beta-L-2',3'-dideoxy-CMP
-
37°C
1.2
beta-L-2'-azido-2'-dCMP
-
1.3
beta-L-2'-azido-2'-dUMP
-
0.82
dCTP
-
reaction with CMP, liver enzyme
0.0146
gemcitabine
wild-type DCK
0.581
gemcitabine monophosphate
-
37°C
0.246
gemcitabine phosphate
wild-type CMPK
0.494
L-(-)-2',3'-dideoxy-3'-thia-CMP
-
37°C
0.25
L-(-)-2',3'-dideoxy-5-fluoro-3'-thia-CMP
-
37°C, His-tagged UMP/CMP kinase
additional information
additional information
Km values of mutant enzymes, overview
-
0.26
ara-CMP
-
pH 7.4, 37°C, His-tagged UMP/CMP kinase
0.34
ara-CMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
0.029
ATP
pH 6.5, when UMP is the other substrate
0.134
ATP
-
reaction with dCMP, enzyme from Novikoff ascites hepatoma
0.204
ATP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.25
ATP
-
37°C, enzyme form UMPK2
0.292
ATP
pH 6.5, reaction with CMP
0.32
ATP
-
reaction with CMP, liver enzyme
0.36
ATP
-
37°C, enzyme form UMPK1
0.58
ATP
-
reaction with UMP, liver enzyme
0.68
ATP
-
reaction with dCMP, liver enzyme
0.272
beta-D-2',3'-dideoxy-CMP
-
37°C
1.037
beta-D-2',3'-dideoxy-CMP
-
37°C
0.15
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C, His-tagged UMP/CMP kinase
0.3
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
2
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C
1
Cidofovir
-
2.3
Cidofovir
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.0053
CMP
-
reaction with ATP, enzyme from Novikoff ascites hepatoma
0.015
CMP
-
37°C, 196-aa and 228-aa enzyme form, in presence of 8 mM MgATP2-
0.02
CMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.026
CMP
-
37°C enzyme form UMPK 1
0.028
CMP
-
37°C, enzyme form UMPK2
0.03
CMP
-
reaction with ATP, liver enzyme
0.07
CMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
0.123
CMP
pH and temperature not specified in the publication, recombinant mutant P64T
0.211
CMP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.98
CMP
-
reaction with dCTP, liver enzyme
3.09
CMP
pH 8.0, 37°C, wild-type enzyme
0.315
cytarabine
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.327
cytarabine
pH and temperature not specified in the publication, recombinant mutant P64T
0.02
D-CMP
-
0.02
D-CMP
-
pH 7.4, 37°C
1
D-dCMP
-
1.3
D-dUMP
-
1.3
D-dUMP
-
pH 7.4, 37°C
0.05
D-UMP
-
0.05
D-UMP
-
pH 7.4, 37°C
0.074
dATP
-
reaction with CMP, liver enzyme
0.42
dATP
-
reaction with UMP, liver enzyme
0.61
dATP
-
reaction with dCMP, liver enzyme
0.017
dCMP
-
pH 8.0, 37°C
0.023
dCMP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.027
dCMP
-
reaction with dATP, liver enzyme
0.11
dCMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.354
dCMP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.513
dCMP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.715
dCMP
-
reaction with ATP, enzyme from Novikoff ascites hepatoma
0.9
dCMP
-
pH 7.4, 37°C, His-tagged UMP/CMP kinase
0.97
dCMP
pH and temperature not specified in the publication, recombinant mutant P64T
1.1
dCMP
-
reaction with dATP, liver enzyme
1.1
dCMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
1.31
dCMP
pH 8.0, 37°C, wild-type enzyme
2.77
dCMP
-
reaction with ATP, liver enzyme
0.1
dUMP
pH 8.0, 37°C, wild-type enzyme
1.034
dUMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.75
L-CMP
-
0.75
L-CMP
-
pH 7.4, 37°C
0.73
L-dCMP
-
pH 7.4, 37°C
0.73
L-dCMP
L-enantiomers have lower reaction rates
0.7
L-dUMP
-
pH 7.4, 37°C
0.7
L-dUMP
L-enantiomers have lower reaction rates
0.02
UMP
-
pH 7.4, 37°C, His-tagged UMP/CMP kinase
0.04
UMP
-
reaction with ATP, liver enzyme
0.043
UMP
-
reaction with ATP, enzyme from Novikoff ascites hepatoma
0.045
UMP
-
pH 7.4, 37°C, His-tagged UMP/CMP kinase
0.053
UMP
-
reaction with dATP, liver enzyme
0.053
UMP
-
37°C, enzyme form UMPK1
0.064
UMP
-
37°C, enzyme form UMPK2
0.067
UMP
-
37°C, 196-aa enzyme form, in presence of 8 mM MgATP2-
0.069
UMP
-
37°C, 228-aa enzyme form, in presence of 8 mM MgATP2-
0.1
UMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.14
UMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
0.25
UMP
pH and temperature not specified in the publication, recombinant mutant P64T
6.3
UMP
pH 8.0, 37°C, wild-type enzyme
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0.47
5-aza-cidofovir
pH and temperature not specified in the publication, recombinant wild-type enzyme
10 - 36
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
0.09
Cidofovir
pH and temperature not specified in the publication, recombinant wild-type enzyme
5.8
dUMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
45
ara-CMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
150
ara-CMP
-
pH 7.4, 37°C, His-tagged UMP-CMP kinase
10
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C
14
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C, GST fusion UMP/CMP kinase
36
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
-
pH 7.4, 37°C, His-tagged UMP-CMP kinase
0.31
CMP
pH and temperature not specified in the publication, recombinant mutant P64T
72
CMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
125
CMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
130
CMP
-
pH 7.4, 37°C, His-tagged UMP-CMP kinase
0.019
cytarabine
pH and temperature not specified in the publication, recombinant mutant P64T
130
cytarabine
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.036
dCMP
pH and temperature not specified in the publication, recombinant mutant P64T
13.4
dCMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
30
dCMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
73
dCMP
-
pH 7.4, 37°C, His-tagged UMP-CMP kinase
0.35
UMP
pH and temperature not specified in the publication, recombinant mutant P64T
0.65
UMP
-
pH 7.0, 25°C, AUA chimeric enzyme
13.7
UMP
-
pH 7.0, 25°C, UAU chimeric enzyme
92
UMP
-
pH 7.4, 37°C, GST fusion UMP-CMP kinase
130
UMP
-
pH 7.4, 37°C, His-tagged UMP-CMP kinase
174
UMP
-
pH 7.0, 25°C, UMP-CMP kinase
188
UMP
pH and temperature not specified in the publication, recombinant wild-type enzyme
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Neale, G.A.M.; Mitchell, A.; Finch, L.R.
Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides
J. Bacteriol.
156
1001-1005
1983
Mycoplasma mycoides
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Ruffner, B.W.; Anderson, E.P.
Adenosine triphosphate: uridine monophosphate-cytidine monophosphate phosphotransferase from Tetrahymena pyriformis
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5994-6002
1969
Tetrahymena pyriformis
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Hurwitz, J.
The enzymatic incorporation of ribonucleotides into polydeoxynucleotide material
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1959
Escherichia coli, Escherichia coli B / ATCC 11303
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Pyrimidine nucleoside monophosphate kinase from rat liver and rat Novikoff ascites hepatoma (EC 2.7.4.14)
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51
321-331
1978
Rattus norvegicus
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UMP-CMP kinase from Tetrahymena pyriformis
Methods Enzymol.
51
331-337
1978
Tetrahymena pyriformis
brenda
Scott, E.M.; Wright, R.C.
Kinetics and equilibria of pyrimidine nucleoside monophosphate kinase from human erythrocytes
Biochim. Biophys. Acta
571
45-54
1979
Homo sapiens
brenda
Maness, P.; Orengo, A.
Activation of rat liver pyrimidine nucleoside monophosphate kinase
Biochim. Biophys. Acta
429
182-190
1976
Rattus norvegicus
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Maness, P.; Orengo, A.
A pyrimidine nucleoside monophosphate kinase from rat liver
Biochemistry
14
1484-1489
1975
Rattus norvegicus
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Kobayashi, S.; Kanayama, K.
NADPH activation of deoxycytidylate kinase in rat liver extract: involvement of an endogenous disulfide reductase system
Biochem. Biophys. Res. Commun.
74
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1977
Rattus norvegicus
brenda
Teng, Y.S.; Chen, S.H.; Scott, C.R.
Human erythrocyte pyrimidine nucleoside monophosphate kinase. Partial purification and properties of two allelic gene products
J. Biol. Chem.
251
4179-4183
1976
Homo sapiens
brenda
Seagrave, J.; Reyes, P.
Pyrimidine nucleoside monophosphate kinase from rat bone marrow cells: chromatographic, electrophoretic, and sedimentation behavior of active and inactive enzyme forms
Arch. Biochem. Biophys.
247
76-83
1986
Rattus norvegicus
brenda
Gravey, T.Q.; Millar, F.K.; Anderson, E.P.
ATP:UMP-CMP phosphotransferase from Tetrahymena pyriformis. II. Kinetic studies and reaction mechanism with UMP
Biochim. Biophys. Acta
302
38-49
1973
Tetrahymena pyriformis
brenda
Kohno, H.; Kumagai, H.; Tochikura, T.
Purification and properties of pyrimidine nucleoside monophosphate kinase from bakers yeast
Agric. Biol. Chem.
47
19-24
1983
Saccharomyces cerevisiae
-
brenda
Seagrave, J.; Reyes, P.
Pyrimidine nucleoside monophosphate kinase from rat bone marrow cells: a kinetic analysis of the reaction mechanism
Arch. Biochem. Biophys.
254
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Rattus norvegicus
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Phosphoryl transfer by a concerted reaction mechanism in UMP/CMP-kinase
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9
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2000
Dictyostelium discoideum
brenda
Zhou, L.; Lacroute, F.; Thornburg, R.
Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase
Plant Physiol.
117
245-254
1998
Arabidopsis thaliana (O04905), Arabidopsis thaliana
brenda
Curbo, S.; Amiri, M.; Foroogh, F.; Johansson, M.; Karlsson, A.
The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal
Biochem. Biophys. Res. Commun.
311
440-445
2003
Drosophila melanogaster
brenda
Van Rompay, A.R.; Johansson, M.; Karlsson, A.
Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme
Mol. Pharmacol.
56
562-569
1999
Homo sapiens (P30085), Homo sapiens
brenda
Okajima, T.; Fukamizo, T.; Goto, S.; Fukui, T.; Tanizawa, K.
Exchange of nucleoside monophosphate-binding domains in adenylate kinase and UMP/CMP kinase
J. Biochem.
124
359-367
1998
Sus scrofa
brenda
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Site-specific mutations of conserved residues in the phosphate-binding loop of the Arabidopsis UMP/CMP kinase alter ATP and UMP binding
Arch. Biochem. Biophys.
358
297-302
1998
Arabidopsis thaliana
brenda
Pearman, A.T.; Castro-Faria-Neto, H.C.; McIntyre, T.M.; Prescott, S.M.; Stafforini, D.M.
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69
2361-2370
2001
Homo sapiens
brenda
Liou, J.Y.; Dutschman, G.E.; Lam, W.; Jiang, Z.; Cheng, Y.C.
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates
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62
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2002
Homo sapiens
brenda
Pasti, C.; Gallois-Montbrun, S.; Munier-Lehmann, H.; Veron, M.; Gilles, A.M.; Deville-Bonne, D.
Reaction of human UMP-CMP kinase with natural and analog substrates
Eur. J. Biochem.
270
1784-1790
2003
Dictyostelium sp., Homo sapiens
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Hewitt, M.M.; Carr, J.M.; Williamson, C.L.; Slocum, R.D.
Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis
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43
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2005
Arabidopsis thaliana
brenda
Topalis, D.; Kumamoto, H.; Amaya Velasco, M.F.; Dugue, L.; Haouz, A.; Alexandre, J.A.; Gallois-Montbrun, S.; Alzari, P.M.; Pochet, S.; Agrofoglio, L.A.; Deville-Bonne, D.
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives - a screening based on affinity for the UMP-CMP binding site
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274
3704-3714
2007
Homo sapiens (P30085), Homo sapiens
brenda
Alexandre, J.A.; Roy, B.; Topalis, D.; Pochet, S.; Perigaud, C.; Deville-Bonne, D.
Enantioselectivity of human AMP, dTMP and UMP-CMP kinases
Nucleic Acids Res.
35
4895-4904
2007
Homo sapiens (P30085), Homo sapiens
brenda
Kocabas, N.A.; Aksoy, P.; Pelleymounter, L.L.; Moon, I.; Ryu, J.S.; Gilbert, J.A.; Salavaggione, O.E.; Eckloff, B.W.; Wieben, E.D.; Yee, V.; Weinshilboum, R.M.; Ames, M.M.
Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics
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36
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2008
Homo sapiens (P30085)
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Xu, Y.; Johansson, M.; Karlsson, A.
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria
J. Biol. Chem.
283
1563-1571
2008
Homo sapiens (Q5EBM0), Homo sapiens
brenda
Lorenz, T.; Reinstein, J.
The influence of proline isomerization and off-pathway intermediates on the folding mechanism of eukaryotic UMP/CMP kinase
J. Mol. Biol.
381
443-455
2008
Dictyostelium discoideum (P20425), Dictyostelium discoideum
brenda
Topalis, D.; Kumamoto, H.; Alexandre, J.A.; Dugue, L.; Pochet, S.; Berteina-Raboin, S.; Agrofoglio, L.A.; Deville-Bonne, D.
Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase
Nucleosides Nucleotides Nucleic Acids
26
1369-1373
2007
Homo sapiens (P30085), Homo sapiens
brenda
Alexandre, J.A.; Roy, B.; Topalis, D.; Perigaud, C.; Deville-Bonne, D.
Enantio-selectivity of human nucleoside monophosphate kinases
Nucleosides Nucleotides Nucleic Acids
26
1375-1379
2007
Homo sapiens
brenda
Liou, J.Y.; Lai, H.R.; Hsu, C.H.; Chang, W.L.; Hsieh, M.J.; Huang, Y.C.; Cheng, Y.C.
Modulation of human UMP/CMP kinase affects activation and cellular sensitivity of deoxycytidine analogs
Biochem. Pharmacol.
79
381-388
2010
Homo sapiens
brenda
Tsao, N.; Lee, M.H.; Zhang, W.; Cheng, Y.C.; Chang, Z.F.
The contribution of CMP kinase to the efficiency of DNA repair
Cell Cycle
14
354-363
2015
Homo sapiens (P30085)
brenda
Topalis, D.; Nogueira, T.C.; De Schutter, T.; El Amri, C.; Krecmerova, M.; Naesens, L.; Balzarini, J.; Andrei, G.; Snoeck, R.
Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1
Oncotarget
7
10386-10401
2016
Homo sapiens (P30085)
brenda
Liu, N.Q.; De Marchi, T.; Timmermans, A.; Trapman-Jansen, A.M.; Foekens, R.; Look, M.P.; Smid, M.; van Deurzen, C.H.; Span, P.N.; Sweep, F.C.; Brask, J.B.; Timmermans-Wielenga, V.; Foekens, J.A.; Martens, J.W.; Umar, A.
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients
Sci. Rep.
6
32027
2016
Homo sapiens (P30085), Homo sapiens
brenda
Kikuchi, M.; Kizaki, K.; Shigeno, S.; Toji, N.; Ishiguro-Oonuma, T.; Koshi, K.; Takahashi, T.; Hashizume, K.
Newly identified interferon tau-responsive Hes family BHLH transcription factor 4 and cytidine/uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
Domest. Anim. Endocrinol.
68
64-72
2019
Bos taurus
brenda
Zhang, X.; Zhang, K.; Zhang, Y.
Pigment epithelium-derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2 A potential treatment strategy for missed abortion
Int. J. Mol. Med.
45
1436-1446
2020
Homo sapiens (Q5EBM0), Homo sapiens
brenda
Chen, S.; Wang, X.; Ye, X.; Ma, D.; Chen, C.; Cai, J.; Fu, Y.; Cheng, X.; Chen, Y.; Gong, X.; Jin, J.
Identification of human UMP/CMP kinase 1 as doxorubicin binding target using protein microarray
SLAS Discov.
22
1007-1015
2017
Homo sapiens (P30085), Homo sapiens
brenda