EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
2.4.1.18 | 1,4-alpha-glucan branching enzyme |
A-549 cell |
- |
660544 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
A-549 cell |
- |
705001 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
A-549 cell |
- |
738659 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
A-549 cell |
- |
692332 |
1.3.1.48 | 13,14-dehydro-15-oxoprostaglandin 13-reductase |
A-549 cell |
- |
746356 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
- |
668172, 685958, 689069, 695883, 740148, 740159 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
lung adenocarcinoma cell line |
667558, 668173 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
A-549 cell |
up-regulation of cyclooxygenase-2 expression by pro-inflammatory cytokines is accompanied by down-regluation of 15-hydroxyprostaglandin dehydrogenase expression. Over-expression of cyclooxygenase-2 but not -1 also attenuates 15-hydroxyprostaglandin dehydrogenase expression. Similarly, overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits interleukin 1beta-induced cyclooxygenase-2 expression and results in apoptosis. The levels of 15-hydroxyprostaglandin dehydrogenase expression in transfected cells correlate positively with those of mesenchymal markers, and negatively with those of epithelial markers |
689843 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
A-549 cell |
- |
740924 |
2.7.7.84 | 2'-5' oligoadenylate synthase |
A-549 cell |
- |
722625, 762508 |
2.7.7.84 | 2'-5' oligoadenylate synthase |
A-549 cell |
OAS1 and OAS3 transcripts are constitutively expressed |
738223 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
A-549 cell |
- |
750402 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
A-549 cell |
lung epithelial cell |
682912 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
A-549 cell |
lung epithelial cell |
682912 |
3.1.3.5 | 5'-nucleotidase |
A-549 cell |
- |
751918, 752251 |
2.3.1.37 | 5-aminolevulinate synthase |
A-549 cell |
sodium butyrate treatment activates ALAS2 gene transcription |
685795 |
2.7.1.105 | 6-phosphofructo-2-kinase |
A-549 cell |
- |
730530 |
2.7.1.105 | 6-phosphofructo-2-kinase |
A-549 cell |
PFKFB4 is overexpressed in human cancers |
730530 |
6.2.1.1 | acetate-CoA ligase |
A-549 cell |
- |
744656 |
6.4.1.2 | acetyl-CoA carboxylase |
A-549 cell |
- |
706433 |
4.2.1.3 | aconitate hydratase |
A-549 cell |
- |
696168 |
3.4.24.86 | ADAM 17 endopeptidase |
A-549 cell |
- |
752817, 754375 |
3.4.24.B9 | ADAM9 endopeptidase |
A-549 cell |
- |
719607 |
3.6.1.13 | ADP-ribose diphosphatase |
A-549 cell |
- |
655991 |
1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
A-549 cell |
- |
763529 |
1.1.1.21 | aldose reductase |
A-549 cell |
lung adenocarcinoma cell line |
668222 |
1.1.1.21 | aldose reductase |
A-549 cell |
type II alveolar epithelial cell line, AR expression analysis |
667420 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
A-549 cell |
- |
714106 |
2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
A-549 cell |
low activity |
658123 |
2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
A-549 cell |
- |
658123 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
A-549 cell |
- |
658123 |
2.4.2.14 | amidophosphoribosyltransferase |
A-549 cell |
- |
736921 |
3.4.17.23 | angiotensin-converting enzyme 2 |
A-549 cell |
- |
710171, 762896, 763707, 764554 |
1.13.11.33 | arachidonate 15-lipoxygenase |
A-549 cell |
- |
704066 |
2.1.1.137 | arsenite methyltransferase |
A-549 cell |
- |
718748, 733451 |
2.1.3.2 | aspartate carbamoyltransferase |
A-549 cell |
- |
756715 |
2.3.3.8 | ATP citrate synthase |
A-549 cell |
- |
672878, 735620, 756645 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
A-549 cell |
- |
702419 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
A-549 cell |
immunostaining of CMO1 in the A549 cells, overview |
726819 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
A-549 cell |
- |
702419 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
A-549 cell |
- |
703406 |
3.4.22.52 | calpain-1 |
A-549 cell |
- |
708761 |
3.4.22.52 | calpain-1 |
A-549 cell |
protein phosphatase 2A functions as a physiological calpain phosphatase to directly dephosphorylate mu-calpain, which leads to decreased calpain activity and suppression of migration and invasion of human lung cancer cells |
680713 |
3.4.22.53 | calpain-2 |
A-549 cell |
- |
707902, 707980 |
3.1.1.1 | carboxylesterase |
A-549 cell |
- |
729652 |
3.1.1.1 | carboxylesterase |
A-549 cell |
enzyme overexpression |
728935 |
3.4.22.55 | caspase-2 |
A-549 cell |
- |
732068, 732733 |
3.4.22.55 | caspase-2 |
A-549 cell |
expression of c-Myc and caspase-2 are crucial for cytochrome c release from mitochondria during cytotoxic stress. Caspase-2 is important for cytosolic Bax to integrate into the outer mitochondrial membrane |
687708 |
3.4.22.55 | caspase-2 |
A-549 cell |
human lung adenocarcinoma cell |
665247 |
3.4.22.56 | caspase-3 |
A-549 cell |
- |
698258 |
3.4.22.57 | caspase-4 |
A-549 cell |
- |
677484 |
3.4.22.61 | caspase-8 |
A-549 cell |
- |
697284, 698258, 708818 |
1.11.1.6 | catalase |
A-549 cell |
- |
660661 |
2.4.1.80 | ceramide glucosyltransferase |
A-549 cell |
high enzyme expression level and content |
736920 |
2.7.1.138 | ceramide kinase |
A-549 cell |
- |
673703, 675274, 691938 |
2.7.1.138 | ceramide kinase |
A-549 cell |
ceramide kinase amplified from an A549 cDNA library |
694006 |
2.7.1.138 | ceramide kinase |
A-549 cell |
human lung adenocarcinoma cell |
673703 |
3.5.1.105 | chitin disaccharide deacetylase |
A-549 cell |
- |
754966 |
3.2.1.14 | chitinase |
A-549 cell |
- |
693471 |
2.7.1.32 | choline kinase |
A-549 cell |
- |
738968 |
2.7.7.15 | choline-phosphate cytidylyltransferase |
A-549 cell |
- |
642902 |
3.4.21.46 | complement factor D |
A-549 cell |
- |
708370 |
2.3.2.32 | cullin-RING-type E3 NEDD8 transferase |
A-549 cell |
- |
745773 |
2.7.11.22 | cyclin-dependent kinase |
A-549 cell |
- |
691272, 737959, 760304 |
4.4.1.1 | cystathionine gamma-lyase |
A-549 cell |
- |
710226 |
4.1.1.84 | D-dopachrome decarboxylase |
A-549 cell |
lung adenocarcinoma cell line |
693465 |
2.7.1.74 | deoxycytidine kinase |
A-549 cell |
- |
672797 |
2.7.1.113 | deoxyguanosine kinase |
A-549 cell |
- |
760985 |
3.6.1.75 | diacylglycerol diphosphate phosphatase |
A-549 cell |
- |
679998 |
2.3.1.57 | diamine N-acetyltransferase |
A-549 cell |
- |
756851 |
2.3.1.57 | diamine N-acetyltransferase |
A-549 cell |
lung-cancer derived cells |
487265 |
2.3.1.57 | diamine N-acetyltransferase |
A-549 cell |
TNFalpha can lead to the induction of NFkappaB signaling with a concomitant increase in spermidine/spermine N1-acetyltransferase expression |
674623 |
3.4.14.5 | dipeptidyl-peptidase IV |
A-549 cell |
- |
699938, 732939 |
1.14.11.51 | DNA N6-methyladenine demethylase |
A-549 cell |
- |
764114 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
- |
691321, 691729, 702564, 702620, 705047, 714463, 727417, 747038, 747693, 747698 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
human lung cancer cells |
693067 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
lung cancer cell |
691619 |
5.6.2.1 | DNA topoisomerase |
A-549 cell |
nonsmall cell lung cancer cell line |
693543 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
A-549 cell |
- |
662925, 678594, 691220, 702620, 705649, 716400, 727171, 747038, 747701, 750475 |
4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase |
A-549 cell |
- |
706019, 748653 |
2.7.7.6 | DNA-directed RNA polymerase |
A-549 cell |
- |
704096, 738671 |
3.6.1.23 | dUTP diphosphatase |
A-549 cell |
- |
758298 |
2.3.2.34 | E2 NEDD8-conjugating enzyme |
A-549 cell |
- |
756564 |
2.7.11.20 | elongation factor 2 kinase |
A-549 cell |
- |
721661, 760810, 760850, 761285 |
3.1.11.2 | exodeoxyribonuclease III |
A-549 cell |
- |
751965 |
1.14.13.225 | F-actin monooxygenase |
A-549 cell |
- |
764574 |
2.3.1.85 | fatty-acid synthase system |
A-549 cell |
- |
720118, 736516, 736922 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
A-549 cell |
- |
753899 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
- |
671840, 713003 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
inducible expression of 10-formyltetrahydrofolate dehydrogenase |
656770 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
A-549 cell |
significantly decreased levels of FDH and its mRNA in 15 tested tumors compared with normal tissues, strong down-regulation of FDH on both the mRNA and protein level in tumors |
392350 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
A-549 cell |
- |
730530 |
3.4.21.75 | Furin |
A-549 cell |
- |
753282 |
2.7.11.16 | G-protein-coupled receptor kinase |
A-549 cell |
- |
761095 |
4.3.2.9 | gamma-glutamylcyclotransferase |
A-549 cell |
- |
705761 |
3.4.24.35 | gelatinase B |
A-549 cell |
- |
707964, 708070 |
2.5.1.29 | geranylgeranyl diphosphate synthase |
A-549 cell |
- |
759541 |
2.3.1.4 | glucosamine-phosphate N-acetyltransferase |
A-549 cell |
- |
757009 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
A-549 cell |
- |
740908, 741464 |
6.3.2.2 | glutamate-cysteine ligase |
A-549 cell |
- |
703592, 715088 |