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Literature summary for 2.1.1.137 extracted from
- Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase (2011), Biochem. Biophys. Res. Commun., 415, 48-53.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3)pLysS cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | an exon-4 and -5 skipping (DELTA4,5) truncated mutant form does not convert arsenite to monomethylarsonate or dimethylarsinic acid | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31100 | - |
x * 31100, truncated exon-4 and -5 skipping (DELTA4,5) mutant form, calculated from amino acid sequence | Homo sapiens |
| 41700 | - |
x * 41700, full-lenth wild type form, calculated from amino acid sequence | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni Sepharose column chromatography, gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| HEK-293 cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| HL-60 cell | - |
Homo sapiens | - |
| K-562 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 31100, truncated exon-4 and -5 skipping (DELTA4,5) mutant form, calculated from amino acid sequence | Homo sapiens |
| ? | x * 41700, full-lenth wild type form, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arsenic (+3 oxidation state) methyltransferase | - |
Homo sapiens |
| AS3MT | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays an important role in the detoxification of arsenicals | Homo sapiens |
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Release 2023.1 (January 2023)
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