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Literature summary for 2.7.1.74 extracted from

  • Pauwels, B.; Korst, A.E.; Pattyn, G.G.; Lambrechts, H.A.; Kamphuis, J.A.; De Pooter, C.M.; Peters, G.J.; Lardon, F.; Vermorken, J.B.
    The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines (2006), BMC Cancer, 6, 142.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of tumors NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
CAL-27 cell lowest specific activity among the cell lines used Homo sapiens
-
ECV304 cell highest specific activity among the cell lines used Homo sapiens
-
FaDu cell
-
 Homo sapiens
-
H292 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of tumors Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?
NTP + 2-chloro-2'-deoxyadenosine
-
 Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens