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Literature summary for 2.3.1.57 extracted from

  • Gerner, E.W.; Kurtts, T.A.; Fuller, D.J.M.; Casero, R.A., Jr.
    Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells (1993), Biochem. J., 294, 491-495.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction Cricetulus griseus
additional information certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6,6-difluorospermidine weak inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cricetulus griseus first enzyme in polyamine catabolism ?
-
?
additional information Homo sapiens first enzyme in polyamine catabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell lung-cancer derived cells Homo sapiens
-
CHO cell
-
Cricetulus griseus
-
melanoma cell line melanoma-derived cells C8146C Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 6,6-difluorospermidine 16.6% of the rate with spermidine Homo sapiens CoA + N1-acetyl-6,6-difluorospermidine
-
?
acetyl-CoA + 7,7-difluorospermidine 19.7% of the rate with spermidine Homo sapiens CoA + N1-acetyl-7,7-difluorospermidine
-
?
acetyl-CoA + spermidine
-
Cricetulus griseus CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermidine
-
Homo sapiens CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine
-
Cricetulus griseus CoA + N1-acetylspermine
-
?
acetyl-CoA + spermine
-
Homo sapiens CoA + N1-acetylspermine
-
?
additional information first enzyme in polyamine catabolism Cricetulus griseus ?
-
?
additional information first enzyme in polyamine catabolism Homo sapiens ?
-
?