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Literature summary for 2.7.11.17 extracted from
- Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609) (2008), Drug Metab. Dispos., 36, 2556-2563.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid | STO-609, triggers the increase of Ca2+ and activation of Ca2+/calmodulin-dependent protein kinase Ialpha | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid | - |
Homo sapiens | |
| 2-[N-(2-hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine | KN-93 | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/calmodulin-dependent protein kinase | - |
Homo sapiens |
| Ca2+/calmodulin-dependent protein kinase Ialpha | - |
Homo sapiens |
| calcium/calmodulin-dependent protein kinase | - |
Homo sapiens |
| CaMK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Ca2+/calmodulin-dependent protein kinase Ialpha is known as a downstream Ca2+/calmodulin-dependent protein kinase kinase effector, contributes to the aryl hydrocarbon receptor cascade | Homo sapiens |
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