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Literature summary for 2.7.1.68 extracted from

  • Chakrabarti, R.; Sanyal, S.; Ghosh, A.; Bhar, K.; Das, C.; Siddhanta, A.
    Phosphatidylinositol-4-phosphate 5-kinase 1alpha modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha (2015), J. Biol. Chem., 290, 20893-20903.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K244A the mutant protein localizes in the cytosol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus
-
Homo sapiens 5730
-
nucleus
-
Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99755
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
sumoylation SUMOylation at Lys-244 and Lys-490 directs the enzyme's nuclear entry and its interaction with H3K9me3/HP1-alpha, respectively Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
phosphatidylinositol-4-phosphate 5-kinase1alpha
-
Homo sapiens
PIP5K
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme functions as a member of the rDNA silencing complex Homo sapiens