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Literature summary for 1.1.1.141 extracted from

  • Ding, Y.; Tong, M.; Liu, S.; Moscow, J.A.; Tai, H.H.
    NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer (2005), Carcinogenesis, 26, 65-72.
    View publication on PubMed
Search for more literature for 1.1.1.141

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of wild-type and mutant enzymes in AD-293 cells using an adenovirus shuttle vector Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information injection of wild-type enzyme, but not mutant enzyme, into mice transfected with A549 cells, reduces the ability of the cancer cell to proliferate in the mice, transfected A549 cells overexpressing the enzyme undergo apoptosis, overview Homo sapiens
Y151F site-directed mutagenesis, highly reduced activity compared to the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Homo sapiens
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens