Cloned (Comment) | Organism |
---|---|
expression in A-549 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of the chitin-cleaving domain abolishes the chitinase activity, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allosamidin | inhibits by direct blocking of the enzyme or blocking of target binding | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | acidic mammalian chitinase plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses, it regulates epithelial cell apoptosis via a chitinolytic-independent mechanism, AMCase induces phosphorylations by Akt activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
pulmonary epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-D-N,N'-diacetylchito-bioside + H2O | - |
Homo sapiens | 4-methylumbelliferone + D-N,N'-diacetylchito-bioside | - |
? | |
additional information | acidic mammalian chitinase plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses, it regulates epithelial cell apoptosis via a chitinolytic-independent mechanism, AMCase induces phosphorylations by Akt activation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acidic mammalian chitinase | - |
Homo sapiens |
AMCase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.2 | - |
assay at | Homo sapiens |