Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16739 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | high enzyme expression level and content | Homo sapiens | - |
CL1-5 cell | high enzyme expression level and content | Homo sapiens | - |
lung adenocarcinoma cell | vinorelbine-resistant, high expression of enzyme GCS in lung cancer cells resistant to vinorelbine-induced apoptosis | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Homo sapiens |
glucosylceramide synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Vinca alkaloid vinorelbine induces the enzyme in vinorelbine-resitant cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | genetically silencing the enzyme induces apoptosis with induced ceramide accumulation, accompanied by a decrease in glucosylceramide, and inhibits Bcl-xL function. Simultaneous GCS inhibition and VNR treatment causes a decrease in Bcl-xL expression. Pharmacologically inhibiting enzyme GCS induces ceramide accumulation in vinorelbine-treated A549 and AS2 cells | Homo sapiens |
additional information | vinorelbine works as an anticancer agent by inducing cell growth inhibition and cell apoptosis | Homo sapiens |
physiological function | an increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells, potential mechanism of glucosylceramide synthase-mediated Vinca alkaloid vinorelbine resistance in human lung adenocarcinoma cells, overview | Homo sapiens |