Information on EC 3.1.3.5 - 5'-nucleotidase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
3.1.3.5
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RECOMMENDED NAME
GeneOntology No.
5'-nucleotidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
hydrolysis of phosphoric esters
phosphorous acid anhydride hydrolysis
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
adenosine nucleotides degradation I
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adenosine nucleotides degradation II
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Biosynthesis of secondary metabolites
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guanosine nucleotides degradation I
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guanosine nucleotides degradation II
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guanosine nucleotides degradation III
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inosine 5'-phosphate degradation
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Metabolic pathways
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NAD salvage pathway III
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Nicotinate and nicotinamide metabolism
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Purine metabolism
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pyridine nucleotide cycling (plants)
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Pyrimidine metabolism
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tunicamycin biosynthesis
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UTP and CTP dephosphorylation I
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NAD metabolism
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purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
5'-ribonucleotide phosphohydrolase
Wide specificity for 5'-nucleotides.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-73-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
peanut
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Manually annotated by BRENDA team
No. A-59
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Manually annotated by BRENDA team
Bacillus sp. No. A-59
No. A-59
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Bothrops pradoi
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
formerly Bothrops castelnaudi
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Manually annotated by BRENDA team
pigeonpea, enzymes N-I and N-II
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Manually annotated by BRENDA team
ATCC 22019
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Manually annotated by BRENDA team
ATCC 22019
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
jumbo squid
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Manually annotated by BRENDA team
cod
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Manually annotated by BRENDA team
NTHi strain P860295
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Manually annotated by BRENDA team
ATCC strain 49503
SwissProt
Manually annotated by BRENDA team
subsp. halophilus
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strains: KL4, KL8, GIM, BRO, M106, incognitus, No.5 and No.29
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Manually annotated by BRENDA team
strain NCTC 10139
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Manually annotated by BRENDA team
strain NCTC 10139
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
no activity in Philodryas olfersii
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Manually annotated by BRENDA team
masou
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
starling
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
enzyme has both Mg2+-dependent diphosphohydrolyse/apyrase and 5’-nucleotidase activity
SwissProt
Manually annotated by BRENDA team
strain TG7
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Manually annotated by BRENDA team
strain TG7
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
biotype albensis
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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cytosolic 5'-nucleotidase cN-II is implicated in drug resistance in patients and dephosphorylates 5-fluoro-dUMP, 3'-azido-3-dTMP, 2'-chloro-2'-deoxyAMP, and related compounds, which represent the monophosphorylated forms of nucleoside prodrugs
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(polyphosphate)n + H2O
(polyphosphate)n-1 + phosphate
show the reaction diagram
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1,N6-ethenoadenosine 5'-phosphate + H2O
1,N6-ethenoadenosine ribonucleoside + phosphate
show the reaction diagram
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45% of the activity with 5'-AMP, heart, membrane-bound enzyme
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?
1-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
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1% of the activity with 5’-IMP
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?
2'-chloro-2'-deoxyAMP + H2O
2'-chloro-2'-deoxyadenosine + phosphate
show the reaction diagram
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cNII
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?
2-(cyclohexylethylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylethylthio)adenosine + phosphate
show the reaction diagram
-
-
-
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?
2-(cyclohexylmethylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylmethylthio)adenosine + phosphate
show the reaction diagram
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-
-
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?
2-(cyclohexylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylthio)adenosine + phosphate
show the reaction diagram
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-
-
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?
2-(cyclopentylthio)adenosine 5'-monophosphate + H2O
2-(cyclopentylthio)adenosine + phosphate
show the reaction diagram
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-
-
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?
2-(dioxanylethylthio)adenosine 5'-monophosphate + H2O
2-(dioxanylethylthio)adenosine + phosphate
show the reaction diagram
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-
-
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?
2-(dioxolanylethylthio)adenosine 5'-monophosphate + H2O
2-(dioxolanylethylthio)adenosine + phosphate
show the reaction diagram
-
-
-
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?
2-(hexylthio)adenosine 5'-monophosphate + H2O
2-(hexylthio)adenosine + phosphate
show the reaction diagram
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-
-
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?
2-(propylthio)adenosine 5'-monophosphate + H2O
2-(propylthio)adenosine + phosphate
show the reaction diagram
-
-
-
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?
2-chloro-2'-deoxyadenosine monophosphate + H2O
2-chloro-2'-deoxyadenosine + phosphate
show the reaction diagram
39% of the activity with 5'-AMP
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?
3'-AMP + H2O
adenosine + phosphate
show the reaction diagram
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-
-
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3'-azido-3'deoxy-dTMP + H2O
3'-azido-3'-deoxythymidine + phosphate
show the reaction diagram
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cNII
-
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?
3'-CMP + H2O
cytosine + phosphate
show the reaction diagram
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3'-IMP + H2O
inosine + phosphate
show the reaction diagram
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1% of the activity with 5'-IMP
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?
3-beta-ribofuranosyladenine 5'-monophosphate + H2O
3-beta-ribofuranosyladenine + phosphate
show the reaction diagram
-
24% of the activity with 5'-AMP, heart, membrane-bound enzyme
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?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferol + phosphate
show the reaction diagram
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?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
5'-AMP + H2O
?
show the reaction diagram
5'-AMP + H2O
adenosine + phosphate
show the reaction diagram
5'-CMP + H2O
cytidine + phosphate
show the reaction diagram
5'-CMP + xanthosine
XMP + cytidine
show the reaction diagram
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-
-
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?
5'-dAMP + H2O
deoxyadenosine + phosphate
show the reaction diagram
5'-dCMP + H2O
2'-deoxycytidine + phosphate
show the reaction diagram
5'-dCMP + H2O
deoxycytidine + phosphate
show the reaction diagram
5'-dGMP + H2O
deoxyguanosine + phosphate
show the reaction diagram
5'-dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
5'-dTMP + H2O
deoxythymidine + phosphate
show the reaction diagram
5'-dUMP + H2O
deoxyuridine + phosphate
show the reaction diagram
5'-dUMP + H2O
deoxyuridne + phosphate
show the reaction diagram
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i.e. 2'-deoxyuridine 5'-phosphate
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?
5'-GMP + H2O
guanidine + phosphate
show the reaction diagram
5'-GMP + H2O
guanosine + phosphate
show the reaction diagram
5'-GMP + xanthosine
XMP + guanosine
show the reaction diagram
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-
-
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?
5'-IMP + H2O
?
show the reaction diagram
5'-IMP + H2O
deoxyinosine + phosphate
show the reaction diagram
5'-IMP + H2O
inosine + phosphate
show the reaction diagram
5'-IMP + xanthosine
XMP + inosine
show the reaction diagram
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-
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?
5'-TMP + H2O
thymidine + phosphate
show the reaction diagram
5'-UMP + H2O
uridine + phosphate
show the reaction diagram
5'-UMP + xanthosine
XMP + uridine
show the reaction diagram
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-
-
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?
5'-XMP + H2O
xanthosine + phosphate
show the reaction diagram
5-fluoro-dUMP + H2O
5-fluoro-uridine + phosphate
show the reaction diagram
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cNII
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?
6-chloropurine ribonucleoside 5'-monophosphate + H2O
6-chloropurine ribonucleoside + phosphate
show the reaction diagram
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50% of the activity with 5'-AMP, heart, membrane-bound enzyme
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?
9-beta-D-arabinosyl-2-fluoroadenine monophosphate + H2O
9-beta-D-arabinosyl-2-fluoroadenine + phosphate
show the reaction diagram
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-
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?
adenosine 5'-O-thiophosphate + H2O
?
show the reaction diagram
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6% of the activity with 5'-AMP, heart, membrane-bound enzyme
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?
ADP + 2 H2O
adenosine + 2 phosphate
show the reaction diagram
ADP + H2O
adenosine + diphosphate
show the reaction diagram
AMP + H2O
adenosine + phosphate
show the reaction diagram
ATP + 3 H2O
adenosine + 3 phosphate
show the reaction diagram
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-
-
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?
ATP + H2O
adenosine + phosphate
show the reaction diagram
ATP + H2O
adenosine + tripolyphosphate
show the reaction diagram
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-
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?
bis-p-nitrophenylphosphate + H2O
?
show the reaction diagram
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-
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?
CMP + H2O
cytidine + phosphate
show the reaction diagram
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-
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?
CTP + H2O
?
show the reaction diagram
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30% of the activity with ATP
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?
cyclic 3',5'-AMP + H2O
?
show the reaction diagram
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8.8% of the activity with 5'-AMP
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?
dAMP + H2O
deoxyadenosine + phosphate
show the reaction diagram
91% of the activity with 5'-AMP
-
?
dATP + H2O
?
show the reaction diagram
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83% of the activity with ATP
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?
dCMP + H2O
deoxycytidine + phosphate
show the reaction diagram
dGMP + H2O
deoxyguanosine + phosphate
show the reaction diagram
75% of the activity with 5'-AMP
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?
dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
diphosphate + H2O
2 phosphate
show the reaction diagram
dTMP + H2O
deoxythymidine + phosphate
show the reaction diagram
-
7.5% of the activity with 5'-IMP
-
?
dUMP + H2O
deoxyuridine + phosphate
show the reaction diagram
7% of the activity with 5'-AMP
-
?
FAD + H2O
?
show the reaction diagram
-
microsomal enzyme
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?
GDP + H2O
?
show the reaction diagram
-
135% of the activity with ATP
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?
GMP + H2O
guanosine + phosphate
show the reaction diagram
-
-
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?
GTP + H2O
?
show the reaction diagram
-
100% of the activity with ATP
-
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?
IMP + H2O
inosine + phosphate
show the reaction diagram
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-
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?
inosine + 5'-IMP
5'-IMP + inosine
show the reaction diagram
-
-
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?
inosine + phosphate
5'-IMP + H2O
show the reaction diagram
-
-
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r
ITP + H2O
?
show the reaction diagram
-
108% of the activity with ATP
-
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?
methylthio-IMP + H2O
? + phosphate
show the reaction diagram
-
-
-
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?
p-nitrophenyl phenylphosphonate + H2O
?
show the reaction diagram
-
-
-
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?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
plasma membrane enzyme: 1% of the activity with 5'-AMP, Golgi apparatus enzyme: 39% of the activity with 5'-AMP
-
?
ribavirin + 5'-IMP
?
show the reaction diagram
better substrate than viramidine
-
-
?
thio-GMP + H2o
6-thioguanosine + phosphate
show the reaction diagram
-
-
-
-
?
thio-IMP + H2O
6-thioinosine + phosphate
show the reaction diagram
-
-
-
-
?
TTP + H2O
?
show the reaction diagram
-
133% of the activity with ATP
-
-
?
UDP + H2O
?
show the reaction diagram
-
150% of the activity with ATP
-
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?
UMP + H2O
uridine + phosphate
show the reaction diagram
-
-
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?
UTP + H2O
?
show the reaction diagram
-
53% of the activity with ATP
-
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?
viramidine + 5'-IMP
?
show the reaction diagram
worse substrate than ribavirin
-
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?
XMP + H2O
xanthosine + phosphate
show the reaction diagram
-
-
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?
additional information
?
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