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Literature summary for 3.1.3.5 extracted from

  • Brouwer, C.; Vogels-Mentink, T.M.; Keizer-Garritsen, J.J.; Trijbels, F.J.; Bokkerink, J.P.; Hoogerbrugge, P.M.; van Wering, E.R.; Veerman, A.J.; De Abreu, R.A.
    Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment (2005), Clin. Chim. Acta, 361, 95-103.
    View publication on PubMed
Search for more literature for 3.1.3.5

Application

Application Comment Organism
medicine in patients with acute lymphoblastic leukemia, enzyme activity decreases during 6-mercaptopurine treatment to about 50% of initial activity. After 6 weeks of treatment, there is a significant negative correlation between thio-GMP levels and enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no product inhibition by 6-thioguanosine Homo sapiens
thio-IMP substrate inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
5'-GMP + H2O
-
 Homo sapiens guanosine + phosphate
-
 ?
5'-IMP + H2O
-
 Homo sapiens inosine + phosphate
-
 ?
methylthio-IMP + H2O
-
 Homo sapiens ? + phosphate
-
 ?
thio-GMP + H2o
-
 Homo sapiens 6-thioguanosine + phosphate
-
 ?
thio-IMP + H2O
-
 Homo sapiens 6-thioinosine + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 substrate thio-IMP Homo sapiens
7.5
-
 substrates IMP, methylthio-IMP Homo sapiens
8
-
 substrate thio-GMP Homo sapiens
8.5
-
 substrates GMP, AMP Homo sapiens