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Literature summary for 3.1.3.5 extracted from

  • Kalsi, K.K.; Lawson, C.; McCormack, A.; Kochan, Z.; Yacoub, M.H.; Smolenski, R.T.
    TNF-a reduces the activity of ecto-5'-nucleotidase in human endothelial cells (2000), Adv. Exp. Med. Biol., 486, 149-152.
    View publication on PubMed
Search for more literature for 3.1.3.5

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane anchored by a phospholipase C sensitive glycosyl phosphoinositol linkage Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-AMP + H2O Homo sapiens enzyme is responsible for generation of adenosine from AMP. Adenosine is involved in a number of cardioprotective mechanisms. TNF-alpha may reduce the capacity of human endothelial cels to produce adenosine by a decrease in activity of ecto-5'-nucleotidase. The loss of ecto-5'-nucleotidase may lead to decreased production of anti-inflammatory adenosine and retention of proinflammatory nucleotides adenosine + phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell HUVEC Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
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 Homo sapiens adenosine + phosphate
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 ?
5'-AMP + H2O enzyme is responsible for generation of adenosine from AMP. Adenosine is involved in a number of cardioprotective mechanisms. TNF-alpha may reduce the capacity of human endothelial cels to produce adenosine by a decrease in activity of ecto-5'-nucleotidase. The loss of ecto-5'-nucleotidase may lead to decreased production of anti-inflammatory adenosine and retention of proinflammatory nucleotides Homo sapiens adenosine + phosphate
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 ?

Synonyms

Synonyms Comment Organism
ecto-5'-nucleotidase
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 Homo sapiens