Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.5 extracted from

  • Cali, T.; Fedrizzi, L.; Ottolini, D.; Gomez-Villafuertes, R.; Mellstroem, B.; Naranjo, J.R.; Carafoli, E.; Brini, M.
    Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation (2012), J. Biol. Chem., 287, 18478-18491.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.5

Application

Application Comment Organism
medicine transgenic mice expressing a dominant active mutant of downstream regulatory element antagonist modulator, daDREAM, show a drastic reduction of the amount of transcript of Ca2+-activated nucleotidase. Ca2+-activated nucleotidase down-regulation is also found in neuroblastoma SH-SY5Y cells stably overexpressing wild type DREAM or daDREAM, thus providing a simple cell model to investigate the protein maturation pathway. The down-regulation of CANT1 is associated with reduced protein secretion and increased degradation rates Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCF1
-
-

Synonyms

Synonyms Comment Organism
Cant1
-
 Mus musculus
soluble calcium-activated nucleotidase 1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus transgenic mice expressing a dominant active mutant of downstream regulatory element antagonist modulator, daDREAM, show a drastic reduction of the amount of transcript of Ca2+-activated nucleotidase. Ca2+-activated nucleotidase down-regulation is also found in neuroblastoma SH-SY5Y cells stably overexpressing wild type DREAM or daDREAM, thus providing a simple cell model to investigate the protein maturation pathway. The down-regulation of CANT1 is associated with reduced protein secretion and increased degradation rates down

General Information

General Information Comment Organism
physiological function transgenic mice expressing a dominant active mutant of downstream regulatory element antagonist modulator, daDREAM, show a drastic reduction of the amount of transcript of Ca2+-activated nucleotidase. Ca2+-activated nucleotidase down-regulation is also found in neuroblastoma SH-SY5Y cells stably overexpressing wild type DREAM or daDREAM, thus providing a simple cell model to investigate the protein maturation pathway. The down-regulation of CANT1 is associated with reduced protein secretion and increased degradation rates Mus musculus