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Literature summary for 3.1.3.16 extracted from

  • Zhou, G.; Golden, T.; Aragon, I.V.; Honkanen, R.E.
    Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade (2004), J. Biol. Chem., 279, 46595-46605.
    View publication on PubMed
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
additional information prolonged hypoxia increases the enzyme expression via activation of a specific transcription factor, the hypoxia-inducible factor-1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
5'-UTR sequence, analysis of PP5 promoter sequence and activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP5 is involved in MAPK signal pathways, PP5 suppresses the hypoxia-induced ASK-1/MKK-4/JNK signaling via two mechanisms, 1. by association to ASK-1, 2. by suppressing the phosphorylation of MKK-4, JNK, and c-Jun, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell the enzyme activity is increased in long-term hypoxia Homo sapiens
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HEP-3B cell the enzyme activity is increased in long-term hypoxia Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP5 is involved in MAPK signal pathways, PP5 suppresses the hypoxia-induced ASK-1/MKK-4/JNK signaling via two mechanisms, 1. by association to ASK-1, 2. by suppressing the phosphorylation of MKK-4, JNK, and c-Jun, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PP5
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 Homo sapiens
Ser/Thr protein phosphatase 5
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 Homo sapiens