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Literature summary for 1.14.19.1 extracted from

  • Scaglia, N.; Caviglia, J.M.; Igal, R.A.
    High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts (2005), Biochim. Biophys. Acta, 1687, 141-151.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell lung adenocarcinoma cells Homo sapiens
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lung fibroblast normal lung fibroblasts WI38 and the derived SV40-tranformed strain cells SV40-WI38, SCD protein content 3.3fold increased in SV40-WI38 cells compared to WI38 cells Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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incubation of A-549 cells with 25 microM C6-ceramide for 6 h and 24 h leads to a 45% and 25% decrease in enzyme activity Homo sapiens
additional information
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induction of apoptosis with 40 microM etoposide leads to a 20% decrease in enzyme activity in SV40-transformed WI38 fibroblasts compared to normal WI38 fibroblasts, which are resistant to etoposide-induced apoptosis Homo sapiens
additional information
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SV40-transformed WI38 fibroblasts exhibit a 2.2fold higher enzyme activity compared to normal WI38 cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme activity measured by conversion of 14C-stearic acid to 14C-oleic acid, reverse-phase HPLC Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
SCD
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Homo sapiens