EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.21.61 | Kexin |
hepatocyte |
- |
707332, 731241 |
3.4.21.61 | Kexin |
hepatocyte |
primary |
731229 |
3.4.21.73 | u-Plasminogen activator |
hepatocyte |
primary |
731238 |
3.4.21.75 | Furin |
hepatocyte |
- |
668204, 709747, 717857 |
3.4.21.B1 | hyaluronan-binding serine protease |
hepatocyte |
- |
710611 |
3.4.21.B27 | proprotein convertase 7 |
hepatocyte |
primary |
731888 |
3.4.22.15 | cathepsin L |
hepatocyte |
primary culture |
647905 |
3.4.22.16 | cathepsin H |
hepatocyte |
cultured |
638819 |
3.4.22.38 | cathepsin K |
hepatocyte |
- |
696654 |
3.4.22.40 | bleomycin hydrolase |
hepatocyte |
detected by immunohistochemistry |
683613 |
3.4.22.52 | calpain-1 |
hepatocyte |
- |
709967 |
3.4.22.53 | calpain-2 |
hepatocyte |
- |
709329 |
3.4.22.55 | caspase-2 |
hepatocyte |
- |
753185 |
3.4.22.56 | caspase-3 |
hepatocyte |
- |
698258, 701153 |
3.4.22.59 | caspase-6 |
hepatocyte |
- |
698943 |
3.4.22.59 | caspase-6 |
hepatocyte |
primary |
698943 |
3.4.22.61 | caspase-8 |
hepatocyte |
- |
680908, 696137, 698258, 701153 |
3.4.22.61 | caspase-8 |
hepatocyte |
caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly |
680064 |
3.4.23.34 | cathepsin E |
hepatocyte |
primary hepatocyte cultures |
677830 |
3.4.23.5 | cathepsin D |
hepatocyte |
fetal hepatocyte |
717048 |
3.4.24.23 | matrilysin |
hepatocyte |
- |
708642 |
3.4.24.35 | gelatinase B |
hepatocyte |
- |
700527 |
3.4.24.56 | insulysin |
hepatocyte |
- |
700288 |
3.4.24.56 | insulysin |
hepatocyte |
primary |
683342 |
3.4.24.87 | ADAMTS13 endopeptidase |
hepatocyte |
ADAMTS13 and von Willebrand factor contents, overview |
713533 |
3.5.1.114 | N-acyl-aromatic-L-amino acid amidohydrolase |
hepatocyte |
AA3 expression in the hepatocellular carcinoma cell lines is 5 to 20 times greater than in normal primary hepatocytes |
754228 |
3.5.1.12 | biotinidase |
hepatocyte |
- |
171935 |
3.5.1.23 | ceramidase |
hepatocyte |
- |
752416 |
3.5.1.23 | ceramidase |
hepatocyte |
in rat hepatocytes, neutral CDase signals appear as many foci distributed throughout the cytoplasm partially co-localizing with the LPG85 signal, a marker for lysosomes/late endosomes |
733408 |
3.5.1.25 | N-acetylglucosamine-6-phosphate deacetylase |
hepatocyte |
extreme low activity |
246599 |
3.5.1.92 | pantetheine hydrolase |
hepatocyte |
vanin 1 expression specifically by the centrilobular hepatocytes in zone 3 adjacent to the central vein |
756998, 757002 |
3.5.1.98 | histone deacetylase |
hepatocyte |
- |
-, 756577 |
3.5.3.1 | arginase |
hepatocyte |
24h culture, both enzyme and NOS-2 activity depend strongly on extracellular L-arginine concentrations. Competing for L-arginine influx by addition of L-lysine results in 60-70% inhibition of enzyme. Addition of enzyme inhibitor L-valine to cells leads to 80-90% decrease in enzyme activity and 25% increase in NOS-2 activity |
670421 |
3.5.3.1 | arginase |
hepatocyte |
type I |
701646 |
3.5.3.15 | protein-arginine deiminase |
hepatocyte |
- |
710772 |
3.5.4.3 | guanine deaminase |
hepatocyte |
- |
688300, 688301 |
3.6.1.5 | apyrase |
hepatocyte |
restricted to the canalicular membrane domain of hepatocytes |
-, 718543 |
3.6.1.6 | nucleoside diphosphate phosphatase |
hepatocyte |
restricted to the canalicular membrane domain of hepatocytes |
718543 |
4.1.1.17 | ornithine decarboxylase |
hepatocyte |
- |
-, 747479 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatocyte |
- |
704540 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatocyte |
cultured cells in co-culture with lipopolysaccharide stimulated Kupffer cells |
668962 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatocyte |
higher level of PEPCK mRNA is observed in spherical rat primary hepatocytes on EHS-gel than monolayer hepatocytes on type I collagen |
746970 |
4.1.1.33 | diphosphomevalonate decarboxylase |
hepatocyte |
- |
650487 |
4.1.1.37 | uroporphyrinogen decarboxylase |
hepatocyte |
- |
703118 |
4.1.1.37 | uroporphyrinogen decarboxylase |
hepatocyte |
culture |
4431, 4441 |
4.1.1.37 | uroporphyrinogen decarboxylase |
hepatocyte |
from embryo |
4431, 4441 |
4.1.1.40 | hydroxypyruvate decarboxylase |
hepatocyte |
- |
4543 |
4.1.1.45 | aminocarboxymuconate-semialdehyde decarboxylase |
hepatocyte |
- |
692185, 692186, 727425 |
4.1.2.13 | fructose-bisphosphate aldolase |
hepatocyte |
- |
-, 749848 |
4.1.2.63 | 2-hydroxyacyl-CoA lyase |
hepatocyte |
- |
760638, 761438 |
4.2.1.1 | carbonic anhydrase |
hepatocyte |
carbonic anhydrase XIV |
679413 |
4.2.1.22 | cystathionine beta-synthase |
hepatocyte |
- |
704793 |
4.2.2.8 | heparin-sulfate lyase |
hepatocyte |
- |
37405 |
4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase |
hepatocyte |
from 2- to 3-month-old male C57/B6 mice isolated by collagenase perfusion |
692463 |
4.3.1.17 | L-serine ammonia-lyase |
hepatocyte |
hepatic SDH |
678411 |
4.3.1.19 | threonine ammonia-lyase |
hepatocyte |
primary culture |
210825 |
4.3.1.3 | histidine ammonia-lyase |
hepatocyte |
adjacent to portal triads |
34308 |
4.3.2.1 | argininosuccinate lyase |
hepatocyte |
ASL expression is time-dependently reduced in hypoxia |
652664 |
4.3.2.9 | gamma-glutamylcyclotransferase |
hepatocyte |
- |
704934 |
4.3.2.9 | gamma-glutamylcyclotransferase |
hepatocyte |
weak expression |
720332 |
4.4.1.1 | cystathionine gamma-lyase |
hepatocyte |
- |
663934 |
4.4.1.20 | leukotriene-C4 synthase |
hepatocyte |
- |
692199 |
4.98.1.1 | protoporphyrin ferrochelatase |
hepatocyte |
embryonal, cultured |
34964 |
5.2.1.8 | peptidylprolyl isomerase |
hepatocyte |
- |
704931 |
5.3.99.3 | prostaglandin-E synthase |
hepatocyte |
- |
746707 |
5.4.99.7 | Lanosterol synthase |
hepatocyte |
- |
693249, 703421 |
5.4.99.7 | Lanosterol synthase |
hepatocyte |
primary hepatocyte |
661036 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
hepatocyte |
- |
691495 |
6.2.1.16 | acetoacetate-CoA ligase |
hepatocyte |
primary |
-, 720477 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
hepatocyte |
- |
672490, 674710, 736 |
6.3.1.2 | glutamine synthetase |
hepatocyte |
- |
676918, 693959, 694533 |
6.3.1.2 | glutamine synthetase |
hepatocyte |
glutamine synthetase protein is preferentially expressed in hepatocytes adjacent to oxygen-supplying capillaries and in previously CPS-positive hepatocytes. No shift towards a periportal or pericentral phenotype, overview |
691725 |
6.3.2.2 | glutamate-cysteine ligase |
hepatocyte |
- |
694060, 703807, 704707 |
6.3.2.2 | glutamate-cysteine ligase |
hepatocyte |
primary cell culture |
650330 |
6.3.2.3 | glutathione synthase |
hepatocyte |
- |
677199 |
6.3.2.3 | glutathione synthase |
hepatocyte |
cell culture |
650330 |
6.3.4.16 | carbamoyl-phosphate synthase (ammonia) |
hepatocyte |
- |
1457, 672441, 673597, 691725 |
6.3.4.16 | carbamoyl-phosphate synthase (ammonia) |
hepatocyte |
cultured human primary hepatocytes, express CPS1 at abundant levels |
713715 |
6.3.4.3 | formate-tetrahydrofolate ligase |
hepatocyte |
- |
765141 |
6.3.4.5 | argininosuccinate synthase |
hepatocyte |
- |
692607 |
6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) |
hepatocyte |
primary mouse hepatocytes release CPS1 during Fas ligand-induced apoptotic injury, and CPS1 is detected in hepatocytes upon hypoosmotic stress |
743989 |
7.1.1.9 | cytochrome-c oxidase |
hepatocyte |
- |
-, 693098, 699003 |
7.1.2.2 | H+-transporting two-sector ATPase |
hepatocyte |
- |
718469, 718971 |
7.2.2.8 | P-type Cu+ transporter |
hepatocyte |
Cu-regulated localization in hepatocytes |
735317 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
- |
699977, 712175 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
ATP7B interaction with p62 is a key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile |
669449 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
ATP7B is observed close to the plasma membrane, both at the sinusoidal and at the biliary pole |
668477 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
copper-induced relocalization summarized in |
688298 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
primary and cultured |
701335 |
7.2.2.9 | P-type Cu2+ transporter |
hepatocyte |
primary, ATP7B is highly expressed in hepatocytes |
698990 |
7.6.2.1 | P-type phospholipid transporter |
hepatocyte |
- |
246839, 667175 |
7.6.2.1 | P-type phospholipid transporter |
hepatocyte |
canalicular membrane |
687006 |
7.6.2.2 | ABC-type xenobiotic transporter |
hepatocyte |
- |
210385, 210386, 695397, 747448, 747619 |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
hepatocyte |
- |
746704, 747225 |