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Literature summary for 4.1.1.32 extracted from

  • Yerkovich, S.T.; Rigby, P.J.; Fournier, P.A.; Olynyk, J.K.; Yeoh, G.C.T.
    Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes (2004), Int. J. Biochem. Cell Biol., 36, 1462-1472.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
interleukin-10 added to cell culture medium in combination with interleukin-1beta, reduces mRNA and enzyme level Rattus norvegicus
interleukin-1beta added to cell culture medium in combination with interleukin-10, reduces mRNA and enzyme level Rattus norvegicus
additional information reduced expression of mRNA when cells are cultured in conditioned medium obtained from LPS-stimulated Kupffer cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + oxaloacetate Rattus norvegicus first committed step of gluconeogenesis GDP + phosphoenolpyruvate + CO2
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male Wistar albino rats
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte cultured cells in co-culture with lipopolysaccharide stimulated Kupffer cells Rattus norvegicus
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liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + oxaloacetate
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Rattus norvegicus GDP + phosphoenolpyruvate + CO2
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?
GTP + oxaloacetate first committed step of gluconeogenesis Rattus norvegicus GDP + phosphoenolpyruvate + CO2
-
?