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Information on EC 3.4.22.55 - caspase-2

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.55 caspase-2
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Word Map
  • 3.4.22.55
  • proapoptotic
  • parp
  • caspase-dependent
  • anti-apoptotic
  • raidd
  • apoptosis-inducing
  • bcl-xl
  • tunel
  • polyadp-ribose
  • z-vad-fmk
  • jurkat
  • p53-induced
  • p53-dependent
  • etoposide
  • caspases-2
  • pan-caspase
  • prodomains
  • apoptosis-related
  • executioner
  • apaf-1
  • damage-induced
  • caspase-mediated
  • death-inducing
  • casps
  • apoptosome
  • anti-fas
  • mitochondria-mediated
  • etoposide-induced
  • non-apoptotic
  • mitochondria-dependent
  • puma
  • bh3-only
  • z-ietd-fmk
  • trail-induced
  • caspase-10
  • ac-devd-cho
  • beta-converting
  • fas-mediated
  • procaspase
  • trail-mediated
  • apoptogenic
  • diagnostics
The expected taxonomic range for this enzyme is: Tetrapoda
Reaction Schemes
strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/-
Synonyms
caspase 2, casp2, ich-1, casp-2, caspase-2l, nedd-2, caspase-2s, ich-1 protease, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/-
show the reaction diagram
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