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Information on EC - cytochrome-c oxidase

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IUBMB Comments
An oligomeric membrane heme-Cu:O2 reductase-type enzyme that terminates the respiratory chains of aerobic and facultative aerobic organisms. The reduction of O2 to water is accompanied by the extrusion of four protons. The cytochrome-aa3 enzymes of mitochondria and many bacterial species are the most abundant group, but other variations, such as the bacterial cytochrome-cbb3 enzymes, also exist. All of the variants have a conserved catalytic core subunit (subunit I) that contains a low-spin heme (of a- or b-type), a binuclear metal centre composed of a high-spin heme iron (of a-, o-, or b-type heme, referred to as a3, o3 or b3 heme), and a Cu atom (CuB). Besides subunit I, the enzyme usually has at least two other core subunits: subunit II is the primary electron acceptor; subunit III usually does not contain any cofactors, but in the case of cbb3-type enzymes it is a diheme c-type cytochrome. While most bacterial enzymes consist of only 3--4 subunits, the mitochondrial enzyme is much more complex and contains 14 subunits.
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Word Map
  • kaplan-meier
  • univariate
  • all-cause
  • enrol
  • 5-year
  • january
  • population-based
  • log-rank
  • registry
  • coronary
  • december
  • confound
  • resect
  • comorbidities
  • worse
  • smoking
  • demographic
  • stratified
  • infarction
  • smoke
  • covariates
  • clinicopathological
  • postoperative
  • radiotherapy
  • admission
  • high-risk
  • disease-free
  • preoperative
  • adjuvant
  • progression-free
  • insurance
  • stratification
  • cyclooxygenase
  • staging
  • interquartile
  • nutrition
  • medicine
  • analysis
  • drug development
The enzyme appears in viruses and cellular organisms
Reaction Schemes
A-protein, Aa3 terminal Oxidase, AED, ba3 cytochrome c oxidase, ba3-type cytochrome c oxidase, caa3 cytochrome c oxidase, caa3-type cytochrome c oxidase, cbb3, cbb3 cytochrome c oxidase, cbb3-2 oxidase, more
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O
show the reaction diagram