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Literature summary for 4.2.99.18 extracted from

  • Tomasi, M.L.; Iglesias-Ara, A.; Yang, H.; Ramani, K.; Feo, F.; Pascale, M.R.; Luz Martinez-Chantar, M.; Mato, J.M.; Lu, S.C.
    S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis (2009), Gastroenterology, 136, 1025-1036.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.99.18

Activating Compound

Activating Compound Comment Organism Structure
oxidative stress
-
 Mus musculus
S-adenosylmethionine S-adenosylmethionine co-treatment is able to increase APEX1 protein levels Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cycloheximide treatment decreases APEX1 protein levels as compared with untreated mouse hepatocytes Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus APEX1 is a protein involved both in the base excision repair pathways of DNA lesions and in the regulation of gene expression as a redox coactivator of different transcription factors, such as early growth response protein-1 ?
-
 ?
additional information Mus musculus apurinic/apyrimidinic endonuclease 1 participates in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites ?
-
 ?
additional information Mus musculus regulation of APEX1 expression by S-adenosylmethionine, which may be one of the mechanisms of hepatocellular carconom formation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mice deficient in methionine adenosyltransferase 1a have chronic hepatic deficiency of S-adenosylmethionine and increased oxidative stress, and develop hepatocellular carcinoma
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte from 2- to 3-month-old male C57/B6 mice isolated by collagenase perfusion Mus musculus
-
liver 1-month-old, from male methionine adenosyltransferase 1a knock-out and wild-type mice Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 genomic instability increased in the livers of 1-month-old methionine adenosyltransferase 1a knock-out mice, compared with wild-type mice, whereas Apex1 mRNA and protein levels are reduced by 20% and 50%, in knock-out mice of all ages Mus musculus
additional information
-
 in mouse cultured hepatocytes, APEX1 protein levels decrease by 40% despite the increase in mRNA levels, and treatment with 2 mmol/L S-adenosylmethionine is able to completely prevent it Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APEX1 is a protein involved both in the base excision repair pathways of DNA lesions and in the regulation of gene expression as a redox coactivator of different transcription factors, such as early growth response protein-1 Mus musculus ?
-
 ?
additional information apurinic/apyrimidinic endonuclease 1 participates in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites Mus musculus ?
-
 ?
additional information regulation of APEX1 expression by S-adenosylmethionine, which may be one of the mechanisms of hepatocellular carconom formation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
APEX1
-
 Mus musculus
apurinic/apyrimidinic endonuclease 1
-
 Mus musculus