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Literature summary for 5.6.2.2 extracted from
- Topoisomerase II inhibition involves characteristic chromosomal expression patterns (2008), BMC Genomics, 9, 324.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aroclor 1254 | - |
Homo sapiens |  |
| c-Myc | - |
Mus musculus | |
| doxorubicin | - |
Homo sapiens | |
| etoposide | - |
Mus musculus | |
| trovafloxacin | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Homo sapiens | - |
| lymphoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA + ATP + H2O | - |
Mus musculus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topo IIalpha | isoform | Mus musculus |
| Topo IIbeta | isoform | Mus musculus |
| Topoisomerase II | - |
Mus musculus |
| Topoisomerase II | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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