Literature summary for 6.3.4.16 extracted from

Liu, H.; Dong, H.; Robertson, K.; Liu, C.
DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma (2011), Am. J. Pathol., 178, 652-661.

Search for more literature for 6.3.4.16

Application

Application	Comment	Organism
medicine	human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31327	isoform CPS1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	cultured human primary hepatocytes, express CPS1 at abundant levels	Homo sapiens	-
liver	-	Homo sapiens	-
additional information	hepatocellular carcinoma cell lines Huh7, Huh7.5 and LH86 lack expression of CPS1. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells	down

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Release 2023.1 (January 2023)