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Information on EC 3.4.24.87 - ADAMTS13 endopeptidase

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.87 ADAMTS13 endopeptidase
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Word Map
  • 3.4.24.87
  • thrombotic
  • thrombocytopenic
  • purpura
  • ttp
  • platelet
  • multimers
  • hemolytic
  • anemia
  • microangiopathic
  • autoantibody
  • uremic
  • metalloproteinase
  • remission
  • idiopathic
  • relapse
  • rituximab
  • shear
  • ikappab
  • coagulation
  • microvascular
  • nf-kappab
  • life-threatening
  • thrombi
  • hemostasis
  • intravascular
  • microcirculation
  • relapsing
  • hemostat
  • plasmapheresis
  • vwf:ag
  • disintegrin-like
  • schistocytes
  • drug development
  • prothrombotic
  • diagnostics
  • microthrombosis
  • ristocetin
  • hemolytic-uremic
  • oklahoma
  • medicine
  • splenectomy
  • ikkalpha
  • microthrombi
  • eculizumab
  • coombs
  • shiga
  • d-dimers
  • hellp
  • antiphospholipid
  • fviii
  • ikkbeta
  • apheresis
  • analysis
  • ikkgamma
The enzyme appears in viruses and cellular organisms
Reaction Schemes
The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain
Synonyms
adamts13, adamts-13, von willebrand factor-cleaving protease, vwf-cp, vwf-cleaving protease, adamts 13, von willebrand factor cleaving protease, vwf cleaving protease, vwf-cleaving metalloprotease, metalloprotease adamts-13, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain
show the reaction diagram