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Information on EC 5.6.2.2 - DNA topoisomerase (ATP-hydrolysing)

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IUBMB Comments
The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Synonyms
ATP-dependent topoisomerase, ATP-dependent type I 5'-topoisomerase, deoxyribonucleic acid topoisomerase IIalpha, DNA gyrase, DNA gyrase-B, DNA Top IIbeta, DNA Topo II, DNA topo IIalpha, DNA topoisomerase II, DNA topoisomerase II alpha, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP-dependent breakage, passage and rejoining of double-stranded DNA
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