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Information on EC 3.4.22.61 - caspase-8

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.61 caspase-8
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Word Map
  • 3.4.22.61
  • caspase-9
  • extrinsic
  • trail
  • apoptosis-inducing
  • parp
  • pro-apoptotic
  • anti-apoptotic
  • fas-associated
  • bcl-xl
  • caspase-dependent
  • trail-induced
  • tunel
  • factor-related
  • fas-mediated
  • nf-kappab
  • annexin
  • flip
  • death-inducing
  • apoptosis-related
  • polyadp-ribose
  • jurkat
  • c-flips
  • tnf-related
  • fas-induced
  • pan-caspase
  • necroptosis
  • anti-fas
  • sub-g1
  • z-vad-fmk
  • adp-ribose
  • deoxynucleotidyl
  • apaf-1
  • mitochondria-dependent
  • survivin
  • executioner
  • receptor-induced
  • deltapsim
  • receptor-interacting
  • caspase-mediated
  • transferase-mediated
  • tnf-induced
  • hoechst
  • mitochondria-mediated
  • dutp
  • tunel-positive
  • domain-like
  • bh3-only
  • procaspase-3
  • drug development
  • apoptogenic
  • z-devd-fmk
  • medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala)
Synonyms
caspase 8, casp8, flice, cysteine protease caspase-8, apoptotic cysteine protease, flice/mach, cysteine aspartic acid-specific protease, fadd-like ice, cysteine aspartic acid protease 8, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala)
show the reaction diagram
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