Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary | Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase-type plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme uPA is a serine protease, and together with its membraneassociated receptor uPAR, is part of the uPA/uPAR system, which is an important component of the fibrinolytic system | Homo sapiens |
physiological function | increasing concentrations of the enzyme dose-dependently decrease SR-BI protein expression in the liver and Huh-7 hepatoma cell line..The enzyme decreases both the cellular binding of HDL to Huh-7 hepatocytes, and the selective uptake of HDL-cholesteryl ester from HDL, it decreases the removal of HDL-cholesteryl ester in the liver via suppression of the hepatic SR-BI expression | Homo sapiens |