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Literature summary for 6.3.2.2 extracted from

  • Huang, Z.A.; Yang, H.; Chen, C.; Zeng, Z.; Lu, S.C.
    Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression (2000), Biochim. Biophys. Acta, 1493, 48-55.
    View publication on PubMed
Search for more literature for 6.3.2.2

Activating Compound

Activating Compound Comment Organism Structure
buthionine sulfoximine induction of enzyme expression Rattus norvegicus
diethyl maleate induction of enzyme expression Rattus norvegicus
ethanol feeding in vivo increases the enzyme expression, treatment of hepatocytes induces the expression of only the heavy enzyme subunit Rattus norvegicus
hydrocortisone treatment of hepatocytes induces the expression of only the heavy enzyme subunit Rattus norvegicus
Insulin treatment of hepatocytes induces the expression of only the heavy enzyme subunit Rattus norvegicus
additional information two-thirds partial hepatectomy increases the enzyme expression Rattus norvegicus
tert-butylhydroquinone induction of enzyme expression Rattus norvegicus
Thioacetamide induction of enzyme expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-Glu + L-Cys Rattus norvegicus first step in glutathione biosynthesis ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-Glu + L-Cys
-
 Rattus norvegicus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
ATP + L-Glu + L-Cys first step in glutathione biosynthesis Rattus norvegicus ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?

Synonyms

Synonyms Comment Organism
gamma-Glutamylcysteine synthetase
-
 Rattus norvegicus
GCS
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus