Literature summary for 4.1.1.32 extracted from

Oda, H.; Okuda, Y.; Yoshida, Y.; Kimura, N.; Kakinuma, A.
Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats (2015), Biochem. Biophys. Res. Commun., 466, 306-311 .

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Application

Application	Comment	Organism
medicine	chronic administration of phenobarbital reduces hepatic PEPCK mRNA in streptozotocin-induced diabetic and nondiabetic rats, and phenobarbital reduces blood glucose level in diabetic rats	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	higher level of PEPCK mRNA is observed in spherical rat primary hepatocytes on EHS-gel than monolayer hepatocytes on type I collagen	Rattus norvegicus	-

Expression

Organism	Comment	Expression
Rattus norvegicus	phenobarbital directly suppresses PEPCK gene expression in spherical hepatocytes on EHS-gel, but not in those on type I collagen. Phenobarbital strongly suppresses cAMP-dependent induction of PEPCK gene expression	down

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Release 2023.1 (January 2023)