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Literature summary for 5.4.99.7 extracted from
- The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity (2005), Biochem. Pharmacol., 69, 1041-1048.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Homo sapiens |
| medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Rattus norvegicus |
| medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Macaca fascicularis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BIBB 515 | - |
Homo sapiens |  |
| BIBB 515 | - |
Macaca fascicularis | |
| BIBB 515 | - |
Rattus norvegicus | |
| S23515 | - |
Homo sapiens | |
| S23515 | - |
Macaca fascicularis | |
| S23515 | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-monoepoxysqualene | Homo sapiens | - |
lanosterol | - |
? | |
| 2,3-monoepoxysqualene | Rattus norvegicus | - |
lanosterol | - |
? | |
| 2,3-monoepoxysqualene | Macaca fascicularis | - |
lanosterol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Macaca fascicularis | - |
Cynomolgus | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| hepatocyte | primary hepatocyte | Homo sapiens | - |
| hepatocyte | primary hepatocyte | Rattus norvegicus | - |
| hepatocyte | primary hepatocyte | Macaca fascicularis | - |
| THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-monoepoxysqualene | - |
Homo sapiens | lanosterol | - |
? | |
| 2,3-monoepoxysqualene | - |
Rattus norvegicus | lanosterol | - |
? | |
| 2,3-monoepoxysqualene | - |
Macaca fascicularis | lanosterol | - |
? | |
| 2,3:22,23-diepoxysqualene | - |
Homo sapiens | 24(S),25-epoxylanosterol | - |
? | |
| 2,3:22,23-diepoxysqualene | - |
Rattus norvegicus | 24(S),25-epoxylanosterol | - |
? | |
| 2,3:22,23-diepoxysqualene | - |
Macaca fascicularis | 24(S),25-epoxylanosterol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OSC | - |
Homo sapiens |
| OSC | - |
Rattus norvegicus |
| OSC | - |
Macaca fascicularis |
| oxidosqualene:lanosterol cyclase | - |
Homo sapiens |
| oxidosqualene:lanosterol cyclase | - |
Rattus norvegicus |
| oxidosqualene:lanosterol cyclase | - |
Macaca fascicularis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
S23515 | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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