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Information on EC 4.4.1.1 - cystathionine gamma-lyase

for references in articles please use BRENDA:EC4.4.1.1
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IUBMB Comments
A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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Synonyms
cystathionase, gamma-cystathionase, cystathionine-gamma-lyase, cs-like, cystalysin, cysteine desulfhydrase, l-cysteine desulfhydrase, cystathionine gamma lyase, prb-ra, c-s-lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminobut-2-enoate = 2-iminobutanoate
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spontaneous
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2-iminobutanoate + H2O = 2-oxobutanoate + NH3
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spontaneous
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L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3
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L-cystathionine = L-cysteine + 2-aminobut-2-enoate
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(1a)
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