Activating Compound | Comment | Organism | Structure |
---|---|---|---|
digoxin | 103% activity at 0.1 mM | Leucoraja erinacea | |
N-7[(4-nitrobenzo-2-oxa-1,3-diazol)]-7beta-amino-3alpha,12alpha-dihydroxy-5beta-cholan-24-oyl-2-aminoethanesulfonate | 110% activity at 0.l mM | Leucoraja erinacea | |
p-aminohippuric acid | 107% activity at 0.1 mM | Leucoraja erinacea | |
taurocholate | 103% activity at 0.1 mM | Leucoraja erinacea |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid | 10% residual activity at 1 mM | Leucoraja erinacea | |
gramicidin D | 97% residual activity at 0.01 mM | Leucoraja erinacea | |
GSH | 73% residual activity at 20 mM | Leucoraja erinacea | |
GSSG | 28% residual activity at 0.1 mM | Leucoraja erinacea | |
leukotriene C4 | 9% residual activity at 0.1 mM | Leucoraja erinacea | |
S-(2,4-dinitrophenyl)glutathione | 64% residual activity at 0.0007 mM | Leucoraja erinacea | |
Sulfobromophthalein | 33% residual activity at 0.1 mM | Leucoraja erinacea | |
vanadate | 32% residual activity at 0.1 mM | Leucoraja erinacea | |
verapamil | 87% residual activity at 0.01 mM | Leucoraja erinacea | |
vincristine | 85% residual activity at 0.01 mM | Leucoraja erinacea |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
S-(2,4-dinitrophenyl)glutathione[side 1] | at pH 7.5 and 20°C | Leucoraja erinacea | |
0.4 | - |
ATP | with S-(2,4-dinitrophenyl)glutathione as cosubstrate, at pH 7.5 and 20°C | Leucoraja erinacea | |
0.5 | - |
ATP | with S-glutathione as cosubstrate, at pH 7.5 and 20°C | Leucoraja erinacea | |
12 | - |
S-glutathione[side 1] | at pH 7.5 and 20°C | Leucoraja erinacea |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Leucoraja erinacea | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required in form of Mg-ATP | Leucoraja erinacea |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leucoraja erinacea | Q8QG98 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Leucoraja erinacea | - |
liver | - |
Leucoraja erinacea | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1] | - |
Leucoraja erinacea | ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2] | - |
? | |
ATP + H2O + S-ethylglutathione[side 1] | - |
Leucoraja erinacea | ADP + phosphate + S-ethylglutathione[side 2] | - |
? | |
ATP + H2O + S-glutathione[side 1] | - |
Leucoraja erinacea | ADP + phosphate + S-glutathione[side 2] | - |
? | |
additional information | no activity with adenylyl-imidodiphosphate | Leucoraja erinacea | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 180000, SDS-PAGE | Leucoraja erinacea |
Synonyms | Comment | Organism |
---|---|---|
MRP2 | - |
Leucoraja erinacea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Leucoraja erinacea |