Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9 | Homo sapiens | |
additional information | glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9 | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of caspase-6 by siRNA reduces bile acid-induced apoptosis and caspase-8 activation in Hep-G2-Ntcp cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbobenzyloxy-LEHD-fluoromethyl ketone | - |
Homo sapiens | |
carbobenzyloxy-LEHD-fluoromethyl ketone | - |
Rattus norvegicus | |
carbobenzyloxy-VEID-fluoromethyl ketone | - |
Homo sapiens | |
carbobenzyloxy-VEID-fluoromethyl ketone | - |
Rattus norvegicus | |
N-carbobenzyloxy-IETD-fluoromethyl ketone | - |
Homo sapiens | |
N-carbobenzyloxy-IETD-fluoromethyl ketone | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 | ? | - |
? | |
additional information | Rattus norvegicus | bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 | ? | - |
? | |
procaspase-3 + H2O | Homo sapiens | - |
caspase-3 + ? | - |
? | |
procaspase-3 + H2O | Rattus norvegicus | - |
caspase-3 + ? | - |
? | |
procaspase-8 + H2O | Homo sapiens | activation | caspase-8 + ? | - |
? | |
procaspase-8 + H2O | Rattus norvegicus | activation | caspase-8 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | caspase-6 is activated by caspase-9 | Homo sapiens |
proteolytic modification | caspase-6 is activated by caspase-9 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp | Homo sapiens | - |
Hep-G2 cell | transfected with Ntcp, sodium taurocholate cotransporting polypeptide | Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
hepatocyte | primary | Rattus norvegicus | - |
Huh-7 cell | a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp | Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantification of apoptosis in hepatocytes, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 | Homo sapiens | ? | - |
? | |
additional information | bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 | Rattus norvegicus | ? | - |
? | |
procaspase-3 + H2O | - |
Homo sapiens | caspase-3 + ? | - |
? | |
procaspase-3 + H2O | - |
Rattus norvegicus | caspase-3 + ? | - |
? | |
procaspase-8 + H2O | - |
Homo sapiens | caspase-8 + ? | - |
? | |
procaspase-8 + H2O | - |
Rattus norvegicus | caspase-8 + ? | - |
? | |
procaspase-8 + H2O | activation | Homo sapiens | caspase-8 + ? | - |
? | |
procaspase-8 + H2O | activation | Rattus norvegicus | caspase-8 + ? | - |
? |