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Literature summary for 3.4.22.59 extracted from

  • Rust, C.; Wild, N.; Bernt, C.; Vennegeerts, T.; Wimmer, R.; Beuers, U.
    Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent (2009), J. Biol. Chem., 284, 2908-2916.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9 Homo sapiens
additional information glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information downregulation of caspase-6 by siRNA reduces bile acid-induced apoptosis and caspase-8 activation in Hep-G2-Ntcp cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-LEHD-fluoromethyl ketone
-
Homo sapiens
carbobenzyloxy-LEHD-fluoromethyl ketone
-
Rattus norvegicus
carbobenzyloxy-VEID-fluoromethyl ketone
-
Homo sapiens
carbobenzyloxy-VEID-fluoromethyl ketone
-
Rattus norvegicus
N-carbobenzyloxy-IETD-fluoromethyl ketone
-
Homo sapiens
N-carbobenzyloxy-IETD-fluoromethyl ketone
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 ?
-
?
additional information Rattus norvegicus bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 ?
-
?
procaspase-3 + H2O Homo sapiens
-
caspase-3 + ?
-
?
procaspase-3 + H2O Rattus norvegicus
-
caspase-3 + ?
-
?
procaspase-8 + H2O Homo sapiens activation caspase-8 + ?
-
?
procaspase-8 + H2O Rattus norvegicus activation caspase-8 + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
Sprague-Dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-6 is activated by caspase-9 Homo sapiens
proteolytic modification caspase-6 is activated by caspase-9 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp Homo sapiens
-
Hep-G2 cell transfected with Ntcp, sodium taurocholate cotransporting polypeptide Homo sapiens
-
hepatocyte
-
Homo sapiens
-
hepatocyte primary Rattus norvegicus
-
Huh-7 cell a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantification of apoptosis in hepatocytes, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 Homo sapiens ?
-
?
additional information bile acid-induced apoptosis, e.g. by glycochenodeoxycholic acid, in hepatocytes is caspase-6-dependent. Caspase-6 appears to play an important regulatory role in the promotion of bile acid-induced apoptosis as part of a feedback loop. Inhibition of caspase-9 reduces glycochenodeoxycholic acid-induced activation of caspase-6, whereas inhibition of caspase-6 reduces activation of caspase-8 placing caspase-6 between caspase-9 and caspase-8 Rattus norvegicus ?
-
?
procaspase-3 + H2O
-
Homo sapiens caspase-3 + ?
-
?
procaspase-3 + H2O
-
Rattus norvegicus caspase-3 + ?
-
?
procaspase-8 + H2O
-
Homo sapiens caspase-8 + ?
-
?
procaspase-8 + H2O
-
Rattus norvegicus caspase-8 + ?
-
?
procaspase-8 + H2O activation Homo sapiens caspase-8 + ?
-
?
procaspase-8 + H2O activation Rattus norvegicus caspase-8 + ?
-
?