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3.4.24.71: endothelin-converting enzyme 1

This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.

Word Map on EC 3.4.24.71

Reaction

Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =

Synonyms

ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.71 endothelin-converting enzyme 1

Reference

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Reference on EC 3.4.24.71 - endothelin-converting enzyme 1

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takahashi, M.; Matsushita, Y.; Iijima, Y.; Tanzawa, K.
Purification and characterization of endothelin-converting enzyme from rat lung
J. Biol. Chem.
268
21394-21398
1993
Rattus norvegicus
Manually annotated by BRENDA team
Shimada, K.; Takahashi, M.; Tanzawa, K.
Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells
J. Biol. Chem.
269
18275-18278
1994
Rattus norvegicus
Manually annotated by BRENDA team
Xu, D.; Emoto, N.; Giaid, A.; Slaughter, C.; Kaw, S.; deWit, D.; Yanagisawa, M.
ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Cell
78
473-485
1994
Bos taurus
Manually annotated by BRENDA team
Ahn, K.; Herman, S.B.; Fahnoe, D.C.
Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity
Arch. Biochem. Biophys.
359
258-268
1998
Homo sapiens
Manually annotated by BRENDA team
Cronin, N.B.; Wallace, B.A.
Do the structures of big ET-1 and big ET-3 adopt a similar overall fold? Consequences for endothelin converting enzyme specificity
Biochemistry
38
1721-1726
1999
Homo sapiens
Manually annotated by BRENDA team
Korth, P.; Egidy, G.; Parnot, C.; LeMoullec, J.M.; Corvol, P.; Pinet, F.
Construction, expression and characterization of a soluble form of human endothelin-converting-enzyme-1
FEBS Lett.
417
365-370
1997
Homo sapiens
Manually annotated by BRENDA team
Hasegawa, H.; Hiki, K.; Sawamura, T.; Aoyama, T.; Okamoto, Y.; Miwa, S.; Shimohama, S.; Kimura, J.; Masaki, T.
Purification of a novel endothelin-converting enzyme specific for big endothelin-3
FEBS Lett.
428
304-308
1998
Bos taurus
Manually annotated by BRENDA team
Wallace, E.M.; Moliterni, J.A.; Moskal, M.A.; Neubert, A.D.; Marcopulos, N.; Stamford, L.B.; Trapani, A.J.; Savage, P.; Chou, M.; Jeng, A.Y.
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme
J. Med. Chem.
41
1513-1523
1998
Homo sapiens
Manually annotated by BRENDA team
Bur, D.; Dale, G.E.; Oefner, C.
A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP)
Protein Eng.
14
337-341
2001
Homo sapiens
Manually annotated by BRENDA team
Brands, M.; Ergueden, J.K.; Hashimoto, K.; Heimbach, D.; Schroeder, C.; Siegel, S.; Stasch, J.P.; Weigand, S.
Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis
Bioorg. Med. Chem. Lett.
15
4201-4205
2005
Homo sapiens
Manually annotated by BRENDA team
Awano, S.; Dawson, L.A.; Hunter, A.R.; Turner, A.J.; Usmani, B.A.
Endothelin system in oral squamous carcinoma cells: specific siRNA targeting of ECE-1 blocks cell proliferation
Int. J. Cancer
118
1645-1652
2006
Homo sapiens
Manually annotated by BRENDA team
Gokhale, N.H.; Cowan, J.A.
Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics
J. Biol. Inorg. Chem.
11
937-947
2006
Homo sapiens
Manually annotated by BRENDA team
Trapani, A.J.; Beil, M.E.; Bruseo, C.W.; Savage, P.; Firooznia, F.; Jeng, A.Y.
CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme
J. Cardiovasc. Pharmacol.
44
S211-S215
2004
Homo sapiens
-
Manually annotated by BRENDA team
Berger, Y.; Dehmlow, H.; Blum-Kaelin, D.; Kitas, E.A.; Loeffler, B.M.; Aebi, J.D.; Juillerat-Jeanneret, L.
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells
J. Med. Chem.
48
483-498
2005
Homo sapiens
Manually annotated by BRENDA team
Dibas, A.; Prasanna, G.; Yorio, T.
Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line
J. Ocul. Pharmacol. Ther.
21
196-204
2005
Homo sapiens
Manually annotated by BRENDA team
Hanessian, S.; Gauchet, C.; Charron, G.; Marin, J.; Nakache, P.
Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme
J. Org. Chem.
71
2760-2778
2006
Homo sapiens
Manually annotated by BRENDA team
Klipper, E.; Gilboa, T.; Levy, N.; Kisliouk, T.; Spanel-Borowski, K.; Meidan, R.
Characterization of endothelin-1 and nitric oxide generating systems in corpus luteum-derived endothelial cells
Reproduction
128
463-473
2004
Homo sapiens
Manually annotated by BRENDA team
Raoch, V.; Martinez-Miguel, P.; Arribas-Gomez, I.; Rodriguez-Puyol, M.; Rodriguez-Puyol, D.; Lopez-Ongil, S.
The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1
Br. J. Pharmacol.
152
313-322
2007
Bos taurus
Manually annotated by BRENDA team
Smollich, M.; Goette, M.; Yip, G.W.; Yong, E.S.; Kersting, C.; Fischgraebe, J.; Radke, I.; Kiesel, L.; Wuelfing, P.
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer
Breast Cancer Res. Treat.
106
361-369
2007
Homo sapiens
Manually annotated by BRENDA team
Roosterman, D.; Kempkes, C.; Cottrell, G.S.; Padilla, B.E.; Bunnett, N.W.; Turck, C.W.; Steinhoff, M.
Endothelin-converting enzyme-1 degrades internalized somatostatin-14
Endocrinology
149
2200-2207
2008
Homo sapiens
Manually annotated by BRENDA team
Fisk, L.; Nalivaeva, N.N.; Turner, A.J.
Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells
Exp. Biol. Med.
231
1048-1053
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Dawson, L.A.; Maitland, N.J.; Berry, P.; Turner, A.J.; Usmani, B.A.
Expression and localization of endothelin-converting enzyme-1 in human prostate cancer
Exp. Biol. Med.
231
1106-1110
2006
Homo sapiens
Manually annotated by BRENDA team
Jafri, F.; Ergul, A.
Phosphorylation of endothelin converting enzyme-1 isoforms: relevance to subcellular localization
Exp. Biol. Med.
231
713-717
2006
Homo sapiens
Manually annotated by BRENDA team
Hunter, A.R.; Turner, A.J.
Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells
Exp. Biol. Med.
231
718-722
2006
Homo sapiens
Manually annotated by BRENDA team
Klipper, E.; Levy, N.; Gilboa, T.; Muller, L.; Meidan, R.
Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain
Exp. Biol. Med.
231
723-728
2006
Homo sapiens
Manually annotated by BRENDA team
Jackson, C.D.; Barnes, K.; Homer-Vanniasinkam, S.; Turner, A.J.
Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein
Exp. Biol. Med.
231
794-801
2006
Homo sapiens
Manually annotated by BRENDA team
Kuruppu, S.; Reeve, S.; Ian Smith, A.
Characterisation of endothelin converting enzyme-1 shedding from endothelial cells
FEBS Lett.
581
4501-4506
2007
Homo sapiens
Manually annotated by BRENDA team
Massai, L.; Volpi, N.; Carbotti, P.; Fruschelli, M.; Mencarelli, M.; Pecorelli, A.; Muscettola, M.; Agliano, M.; Alessandrini, C.; Grasso, G.
Endothelin-1 and endothelin-converting enzyme-1 in human granulomatous pathology of eyelid: an immunohistochemical and in situ hybridization study in chalazia
Histol. Histopathol.
22
1343-1354
2007
Homo sapiens
Manually annotated by BRENDA team
Eckman, E.A.; Adams, S.K.; Troendle, F.J.; Stodola, B.A.; Kahn, M.A.; Fauq, A.H.; Xiao, H.D.; Bernstein, K.E.; Eckman, C.B.
Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
J. Biol. Chem.
281
30471-30478
2006
Mus musculus
Manually annotated by BRENDA team
Padilla, B.E.; Cottrell, G.S.; Roosterman, D.; Pikios, S.; Muller, L.; Steinhoff, M.; Bunnett, N.W.
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
J. Cell Biol.
179
981-997
2007
Homo sapiens
Manually annotated by BRENDA team
Suekane, T.; Ikura, Y.; Arimoto, J.; Nakagawa, M.; Kitabayashi, C.; Naruko, T.; Watanabe, T.; Fujiwara, Y.; Oshitani, N.; Maeda, K.; Tanzawa, K.; Hirakawa, K.; Arakawa, T.; Ueda, M.
Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohns disease
J. Clin. Biochem. Nutr.
42
126-132
2008
Homo sapiens
Manually annotated by BRENDA team
Hyndman, K.A.; Evans, D.H.
Endothelin and endothelin converting enzyme-1 in the fish gill: evolutionary and physiological perspectives
J. Exp. Biol.
210
4286-4297
2007
Fundulus heteroclitus (A7LFV6), Fundulus heteroclitus
Manually annotated by BRENDA team
Iwase, A.; Ando, H.; Nagasaka, T.; Goto, M.; Harata, T.; Kikkawa, F.
Distribution of endothelin-converting enzyme-1 and neutral endopeptidase in human endometrium
J. Histochem. Cytochem.
55
1229-1235
2007
Homo sapiens
Manually annotated by BRENDA team
Shirai, N.; Naruko, T.; Ohsawa, M.; Ikura, Y.; Sugama, Y.; Hirayama, M.; Kitabayashi, C.; Ehara, S.; Inoue, T.; Itoh, A.; Haze, K.; Tanzawa, K.; Yoshiyama, M.; Yoshikawa, J.; Ueda, M.
Expression of endothelin-converting enzyme, endothelin-1 and endothelin receptors at the site of percutaneous coronary intervention in humans
J. Hypertens.
24
711-721
2006
Homo sapiens
Manually annotated by BRENDA team
Khamaisi, M.; Raz, I.; Shilo, V.; Shina, A.; Rosenberger, C.; Dahan, R.; Abassi, Z.; Meidan, R.; Lecht, S.; Heyman, S.N.
Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney
Kidney Int.
74
91-100
2008
Rattus norvegicus
Manually annotated by BRENDA team
Daray, F.M.; Colombo, J.R.; Kibrik, J.R.; Errasti, A.E.; Pelorosso, F.G.; Nowak, W.; Cracowski, J.L.; Rothlin, R.P.
Involvement of endothelial thromboxane A2 in the vasoconstrictor response induced by 15-E2t-isoprostane in isolated human umbilical vein
Naunyn Schmiedebergs Arch. Pharmacol.
373
367-375
2006
Homo sapiens
Manually annotated by BRENDA team
Buehler, K.; Ufer, M.; Mueller-Marbach, A.; Brinkmann, U.; Laule, M.; Stangl, V.; Roots, I.; Stangl, K.; Cascorbi, I.
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes
Pharmacogenet. Genomics
17
77-83
2007
Homo sapiens
Manually annotated by BRENDA team
Choi, D.S.; Wang, D.; Yu, G.Q.; Zhu, G.; Kharazia, V.N.; Paredes, J.P.; Chang, W.S.; Deitchman, J.K.; Mucke, L.; Messing, R.O.
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
Proc. Natl. Acad. Sci. USA
103
8215-8220
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Khimji, A.K.; Shao, R.; Rockey, D.C.
Divergent transforming growth factor-beta signaling in hepatic stellate cells after liver injury: functional effects on ECE-1 regulation
Am. J. Pathol.
173
716-727
2008
Rattus norvegicus
Manually annotated by BRENDA team
Keeble, J.E.
Re-sensitization of neuropeptide receptors: should we stop the recycling?
Br. J. Pharmacol.
156
728-729
2009
Homo sapiens
Manually annotated by BRENDA team
Cattaruzza, F.; Cottrell, G.S.; Vaksman, N.; Bunnett, N.W.
Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation
Br. J. Pharmacol.
156
730-739
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Rayhman, O.; Klipper, E.; Muller, L.; Davidson, B.; Reich, R.; Meidan, R.
Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells
Cancer Res.
68
9265-9273
2008
Homo sapiens
Manually annotated by BRENDA team
Peltonen, T.; Taskinen, P.; Naepaenkangas, J.; Leskinen, H.; Ohtonen, P.; Soini, Y.; Juvonen, T.; Satta, J.; Vuolteenaho, O.; Ruskoaho, H.
Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis
Eur. Heart J.
30
242-249
2009
Homo sapiens
Manually annotated by BRENDA team
Lee, S.; Carter, P.R.; Watts, M.N.; Bao, J.R.; Harris, N.R.
Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis
Inflamm. Bowel Dis.
15
1007-1013
2009
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Martinez-Miguel, P.; Raoch, V.; Zaragoza, C.; Valdivielso, J.M.; Rodriguez-Puyol, M.; Rodriguez-Puyol, D.; Lopez-Ongil, S.
Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins
J. Lipid Res.
50
364-375
2009
Bos taurus, Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Schulz, H.; Dale, G.E.; Karimi-Nejad, Y.; Oefner, C.
Structure of human endothelin-converting enzyme I complexed with phosphoramidon
J. Mol. Biol.
385
178-187
2009
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Cerdeira, A.S.; Bras-Silva, C.; Leite-Moreira, A.F.
Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases
Rev. Port. Cardiol.
27
385-408
2008
Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa, Cavia sp.
Manually annotated by BRENDA team
Cottrell, G.S.; Padilla, B.E.; Amadesi, S.; Poole, D.P.; Murphy, J.E.; Hardt, M.; Roosterman, D.; Steinhoff, M.; Bunnett, N.W.
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling
J. Biol. Chem.
284
22411-22425
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Jullien, N.; Makritis, A.; Georgiadis, D.; Beau, F.; Yiotakis, A.; Dive, V.
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors
J. Med. Chem.
53
208-220
2010
Homo sapiens
Manually annotated by BRENDA team
Jin, Z.; Luxiang, C.; Huadong, Z.; Zhiqiang, X.; Lihua, H.; Huiyun, L.
C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis
Microvasc. Res.
78
128-131
2009
Homo sapiens
Manually annotated by BRENDA team
Palmer, J.C.; Kehoe, P.G.; Love, S.
Endothelin-converting enzyme-1 in Alzheimers disease and vascular dementia
Neuropathol. Appl. Neurobiol.
36
487-497
2010
Homo sapiens
Manually annotated by BRENDA team
Raoch, V.; Rodriguez-Pascual, F.; Lopez-Martinez, V.; Medrano-Andres, D.; Rodriguez-Puyol, M.; Lamas, S.; Rodriguez-Puyol, D.; Lopez-Ongil, S.
Nitric oxide decreases the expression of endothelin-converting enzyme-1 through mRNA destabilization
Arterioscler. Thromb. Vasc. Biol.
31
2577-2585
2011
Bos taurus
Manually annotated by BRENDA team
Whyteside, A.R.; Hinsley, E.E.; Lambert, L.A.; McDermott, P.J.; Turner, A.J.
ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms
Can. J. Physiol. Pharmacol.
88
850-854
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, S.; Wang, R.; Chen, L.; Bennett, D.A.; Dickson, D.W.; Wang, D.S.
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimers brain
J. Neurochem.
115
47-57
2010
Homo sapiens
Manually annotated by BRENDA team
Pelayo, J.C.; Poole, D.P.; Steinhoff, M.; Cottrell, G.S.; Bunnett, N.W.
Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones
J. Physiol.
589
5213-5230
2011
Mus musculus
Manually annotated by BRENDA team
Hasdemir, B.; Mahajan, S.; Bunnett, N.W.; Liao, M.; Bhargava, A.
Endothelin-Converting Enzyme-1 Actions Determine Differential Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 at High Agonist Concentrations
Mol. Endocrinol.
26
681-695
2012
Homo sapiens
Manually annotated by BRENDA team
Khamaisi, M.; Skarzinski, G.; Mekler, J.; Zreik, F.; Damouni, R.; Ariel, I.; Bursztyn, M.
Hyperinsulinemia increases placenta endothelin-converting enzyme-1 expression in trophoblasts
Am. J. Hypertens.
25
109-114
2012
Rattus norvegicus (P42893)
Manually annotated by BRENDA team
Sonawane, K.; Barage, S.
Structural analysis of membrane-bound hECE-1 dimer using molecular modeling techniques: insights into conformational changes and Abeta1-42 peptide binding
Amino Acids
47
543-559
2015
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Pacheco-Quinto, J.; Herdt, A.; Eckman, C.; Eckman, E.
Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease
J. Alzheimers Dis.
33
S101
2013
Homo sapiens (P42892)
Manually annotated by BRENDA team
Jensen, D.; Halls, M.; Murphy, J.; Canals, M.; Cattaruzza, F.; Poole, D.; Lieu, T.; Koon, H.; Pothoulakis, C.; Bunnett, N.
Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals
J. Biol. Chem.
289
20283-20294
2014
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Kido-Nakahara, M.; Buddenkotte, J.; Kempkes, C.; Ikoma, A.; Cevikbas, F.; Akiyama, T.; Nunes, F.; Seeliger, S.; Hasdemir, B.; Mess, C.; Buhl, T.; Sulk, M.; Müller, F.; Metze, D.; Bunnett, N.; Bhargava, A.; Carstens, E.; Furue, M.; Steinhoff, M.
Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus
J. Clin. Invest.
124
2683-2695
2014
Homo sapiens (P42892), Homo sapiens, Mus musculus (Q4PZA2), Mus musculus
Manually annotated by BRENDA team
Park, P.; Lee, T.; Cho, E.
Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes
J. Invest. Dermatol.
135
551-559
2015
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Tanneeru, K.; Sahu, I.; Guruprasad, L.
Ligand-based drug design for human endothelin converting enzyme-1 inhibitors
Med. Chem. Res.
22
4401-4409
2013
Homo sapiens (P42892)
-
Manually annotated by BRENDA team
Kuruppu, S.; Chou, S.; Feske, S.; Suh, S.; Hanchapola, I.; Lo, E.; Ning, M.; Smith, A.
Soluble and catalytically active endothelin converting enzyme-1 is present in cerebrospinal fluid of subarachnoid hemorrhage patients
Mol. Cell. Proteomics
13
1091-1094
2014
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Whyteside, A.; Turner, A.; Lambert, D.
Endothelin-converting enzyme-1 (ECE-1) is post-transcriptionally regulated by alternative polyadenylation
PLoS ONE
9
e83260
2014
Homo sapiens (P42892)
Manually annotated by BRENDA team
Heyman, S.N.; Abassi, Z.; Rosenberger, C.; Yaseen, H.; Skarjinski, G.; Shina, A.; Mathia, S.; Krits, N.; Khamaisi, M.
Cyclosporine A induces endothelin-converting enzyme-1 Studies invivo and invitro
Acta Physiol. (Oxf.)
223
e13033
2018
Rattus norvegicus (P42893)
Manually annotated by BRENDA team
Cho, T.J.; Kim, H.J.; Cho, J.
Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis
Anim. Cells Sys.
23
170-175
2019
Rattus norvegicus (P42893)
Manually annotated by BRENDA team
Lu, J.; Willars, G.B.
Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation
Biochem. J.
476
513-533
2019
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team
Boratko, A.; Vereb, Z.; Petrovski, G.; Csortos, C.
TIMAP-protein phosphatase 1-complex controls endothelin-1 production via ECE-1 dephosphorylation
Int. J. Biochem. Cell Biol.
73
11-18
2016
Homo sapiens (P42892)
Manually annotated by BRENDA team
Smith, A.I.; Rajapakse, N.W.; Kleifeld, O.; Lomonte, B.; Sikanyika, N.L.; Spicer, A.J.; Hodgson, W.C.; Conroy, P.J.; Small, D.H.; Kaye, D.M.; Parkington, H.C.; Whisstock, J.C.; Kuruppu, S.
N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin
Sci. Rep.
6
22413
2016
Homo sapiens (P42892)
Manually annotated by BRENDA team
Wu, C.F.; Lee, C.T.; Kuo, Y.H.; Chen, T.H.; Chang, C.Y.; Chang, I.W.; Wang, W.L.
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma
Tumor Biol.
39
1010428317725922
2017
Homo sapiens (P42892), Homo sapiens
Manually annotated by BRENDA team