Application | Comment | Organism |
---|---|---|
drug development | ECE-1 silencing (RNAi) may be a promising ovarian carcinoma anticancer therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of ECE-1 is significantly higher in the solid tumors compared with effusions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | RNAi-induced knockdown of ECE-1 reduces ECE-1 mRNA and protein levels leading to 80% to 90% inhibition of endothelin-1 secretion by the ovarian carcinoma cells, analysation of cell's behaviour and effect on the cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-1 + H2O | Homo sapiens | - |
endothelin-1 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ES-2 cell | - |
Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-1 + H2O | - |
Homo sapiens | endothelin-1 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
endothelin-converting enzyme-1 | - |
Homo sapiens |