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Literature summary for 3.4.24.71 extracted from

  • Rayhman, O.; Klipper, E.; Muller, L.; Davidson, B.; Reich, R.; Meidan, R.
    Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells (2008), Cancer Res., 68, 9265-9273.
    View publication on PubMed
Search for more literature for 3.4.24.71

Application

Application Comment Organism
drug development ECE-1 silencing (RNAi) may be a promising ovarian carcinoma anticancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of ECE-1 is significantly higher in the solid tumors compared with effusions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information RNAi-induced knockdown of ECE-1 reduces ECE-1 mRNA and protein levels leading to 80% to 90% inhibition of endothelin-1 secretion by the ovarian carcinoma cells, analysation of cell's behaviour and effect on the cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
big endothelin-1 + H2O Homo sapiens
-
 endothelin-1 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ES-2 cell
-
 Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
big endothelin-1 + H2O
-
 Homo sapiens endothelin-1 + ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens
endothelin-converting enzyme-1
-
 Homo sapiens