3.4.24.71: endothelin-converting enzyme 1

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For detailed information about endothelin-converting enzyme 1, go to the full flat file.

Word Map on EC 3.4.24.71

3.4.24.71

endothelins

phosphoramidon

artery

vasoconstrictor

endopeptidase

cardiovascular

hypertension

cardiac

pulmonary

angiotensin

neprilysin

tone

vasoactive

metalloprotease

vessel

coronary

phosphoramidon-sensitive

metallopeptidases

contractile

preproet-1

vasospasm

thiorphan

atrial

natriuretic

pressor

ventricular

aortic

angiotensin-converting

preproendothelin-1

endothelium-derived

et-1-induced

insulin-degrading

drug development

baecs

hemodynamic

medicine

vasopeptidase

etb-receptors

3.4.24.11

metalloendopeptidase

subarachnoid

chymase

conscious

ednra

sarafotoxin

basilar

ppet-1

21-amino

prepro

enzyme-2

bosentan

et-1-mediated

Reaction

Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =

Synonyms

ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.71 endothelin-converting enzyme 1

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Results	in table
11	Activating Compound
2282	AA Sequence
12	Application
1	CAS Registry Number
21	Cloned(Commentary)
1	Crystallization (Commentary)
829	Disease/ Diagnostics
8	Expression
19	General Information
59	IC50 Value
217	Inhibitors
17	Ki Value [mM]
13	KM Value [mM]
56	Localization
21	Metals/Ions
15	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
283	Organism
1	PDB ID
12	pH Optimum
4	pH Range
6	Posttranslational Modification
11	Protein Variants
6	Purification (Commentary)
3	Reaction
1	Reaction Type
85	Reference
1	Renatured (Commentary)
125	Source Tissue
5	Specific Activity [micromol/min/mg]
106	Substrates and Products (Substrate)
10	Subunits
150	Synonyms
9	Temperature Optimum [°C]
3	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.71 - endothelin-converting enzyme 1

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107600

Homo sapiens

2 * 110000, SDS-PAGE, 2 * 107600, MALDI

649414

110000

Homo sapiens

2 * 110000, SDS-PAGE, 2 * 107600, MALDI

649414

115000

Homo sapiens

2 * 110000-140000, gel filtration, 2 * 115000, isoenzyme sECE, gel filtration

126000

1 * 126000, SDS-PAGE

130000

1 * 130000, SDS-PAGE

140000

SDS-PAGE

170000 - 190000

rat, FPLC gel filtration

232000

gel filtration

250000 - 300000

gel filtration

78000

crystallization, 680 residues of monomeric enzyme (extracellular domain, residues 90-770)

699564

80000

2 entries

85520

Rattus norvegicus

rat, deduced from nucleotide sequence

31469

85610

Bos taurus

bovine, deduced from nucleotide sequence

31470

86000

Rattus norvegicus

1 * 86000, deglycosylated enzyme, SDS-PAGE

31469