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Literature summary for 3.4.24.71 extracted from

  • Shimada, K.; Takahashi, M.; Tanzawa, K.
    Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells (1994), J. Biol. Chem., 269, 18275-18278.
    View publication on PubMed
Search for more literature for 3.4.24.71

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-cells Rattus norvegicus
rat Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by thiorphan, captopril Rattus norvegicus
phosphoramidon
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc metalloproteinase, zinc-binding domain Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85520
-
 rat, deduced from nucleotide sequence Rattus norvegicus
86000
-
 1 * 86000, deglycosylated enzyme, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein highly glycosylated with 10 possible N-linked glycosylated sites Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
endothelium vascular Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Human big endothelin 1 + H2O best substrate Rattus norvegicus Endothelin 1 + big endothelin 1(21-38)
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 86000, deglycosylated enzyme, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus