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Literature summary for 3.4.24.71 extracted from

  • Kido-Nakahara, M.; Buddenkotte, J.; Kempkes, C.; Ikoma, A.; Cevikbas, F.; Akiyama, T.; Nunes, F.; Seeliger, S.; Hasdemir, B.; Mess, C.; Buhl, T.; Sulk, M.; Müller, F.; Metze, D.; Bunnett, N.; Bhargava, A.; Carstens, E.; Furue, M.; Steinhoff, M.
    Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus (2014), J. Clin. Invest., 124, 2683-2695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.71

Inhibitors

Inhibitors Comment Organism Structure
SM-19712 0.01 mM used in assay conditions Homo sapiens
SM-19712 0.01 mM used in assay conditions Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
endosome
-
 Mus musculus 5768
-
extracellular
-
 Homo sapiens
-
-
extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
big endothelin-1 + H2O Homo sapiens big endothelin-1 is hydrolyzed at Asp18-Ile19 endothelin-1 + ?
-
 ?
big endothelin-1 + H2O Mus musculus big endothelin-1 is hydrolyzed at Asp18-Ile19 endothelin-1 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42892
-
-
Mus musculus Q4PZA2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dorsal root ganglion
-
 Mus musculus
-
nerve
-
 Homo sapiens
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
big endothelin-1 + H2O big endothelin-1 is hydrolyzed at Asp18-Ile19 Homo sapiens endothelin-1 + ?
-
 ?
big endothelin-1 + H2O big endothelin-1 is hydrolyzed at Asp18-Ile19 Mus musculus endothelin-1 + ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens
ECE-1
-
 Mus musculus
endothelin-converting enzyme 1
-
 Homo sapiens
endothelin-converting enzyme 1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is a key regulator of endothelin 1-induced pruritus and neural signaling of itch Homo sapiens
physiological function the enzyme is a key regulator of endothelin 1-induced pruritus and neural signaling of itch Mus musculus