3.4.24.71: endothelin-converting enzyme 1
This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.
Word Map on EC 3.4.24.71
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3.4.24.71
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endothelins
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phosphoramidon
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artery
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vasoconstrictor
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endopeptidase
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cardiovascular
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hypertension
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cardiac
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pulmonary
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angiotensin
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neprilysin
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tone
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vasoactive
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metalloprotease
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vessel
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coronary
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phosphoramidon-sensitive
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metallopeptidases
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contractile
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preproet-1
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vasospasm
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thiorphan
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atrial
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natriuretic
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pressor
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ventricular
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aortic
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angiotensin-converting
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preproendothelin-1
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endothelium-derived
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et-1-induced
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insulin-degrading
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drug development
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baecs
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hemodynamic
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medicine
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vasopeptidase
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etb-receptors
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3.4.24.11
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metalloendopeptidase
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subarachnoid
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chymase
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conscious
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ednra
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sarafotoxin
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basilar
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ppet-1
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21-amino
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prepro
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enzyme-2
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bosentan
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et-1-mediated
- 3.4.24.71
- endothelins
- phosphoramidon
- artery
-
vasoconstrictor
- endopeptidase
- cardiovascular
- hypertension
- cardiac
- pulmonary
- angiotensin
- neprilysin
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tone
-
vasoactive
- metalloprotease
- vessel
- coronary
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phosphoramidon-sensitive
- metallopeptidases
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contractile
-
preproet-1
- vasospasm
- thiorphan
-
atrial
-
natriuretic
-
pressor
- ventricular
- aortic
-
angiotensin-converting
- preproendothelin-1
-
endothelium-derived
-
et-1-induced
-
insulin-degrading
- drug development
-
baecs
-
hemodynamic
- medicine
-
vasopeptidase
-
etb-receptors
-
3.4.24.11
- metalloendopeptidase
-
subarachnoid
- chymase
-
conscious
-
ednra
- sarafotoxin
-
basilar
-
ppet-1
-
21-amino
-
prepro
- enzyme-2
- bosentan
-
et-1-mediated
Reaction
Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =
Synonyms
ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1
ECTree
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Activating Compound
Activating Compound on EC 3.4.24.71 - endothelin-converting enzyme 1
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K49-P1-20
i.e. N-terminal domain of Bothrops asper myotoxin II, 2fold enhancement of enzyme activity (maximal stimulation with 0.0001 mg/ml), activation concentration 50 (AC50) is 0.00192 mM
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the peptidase inhibitor CGS-26303, bigendothelin-1, and phosphoramidon, though not thiorphan, a neutral endopeptidase inhibitor, increase endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1, CGS-26303 and big endothelin increase ECE-1 promoter activity, the stimulation is abolished by cycloheximide, overview
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additional information
enzyme expression is twofold increased during transfer from seawater to freshwater, and sixfold during transfer from freshwater to seawater, while chronic exposure to fresh- or seawater has no effet on the enzyme, overview
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additional information
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enzyme expression is twofold increased during transfer from seawater to freshwater, and sixfold during transfer from freshwater to seawater, while chronic exposure to fresh- or seawater has no effet on the enzyme, overview
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additional information
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protein kinase C epsilon, PKCepsilon, stimulates ECE-1 activity, overview
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additional information
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protein kinase C epsilon, PKCepsilon, stimulates the amyloid-beta peptide degradation by ECE-1 in transgenic mice, overview
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additional information
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diabetes and radiocontrast media increase medullary, but not cortical endothelin converting enzyme-1 content in the kidney, in vivo, the induction of diabetes or the administration of contrast media rises the enzyme activity 4-5fold, but 15fold when diabetic rats are given contrast media, the in vitro activity is increased 3-4fold, overview
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